Dott. Christian Lunetta
Attività medica: Primario, Direttore Dipartimento Riabilitazione Neuromotoria Attività di ricerca: Responsabile Lab. Ricerca, Bench sideDove trovarlo
Esperienze professionali
- Dal 01 Maggio 2024 è il Primario dell’U.O. di Riabilitazione Neurologica / SLA degli Istituti Clinici Scientifici Maugeri IRCCS, Milano
- Dal 01 ottobre 2023 è il Responsabile dell’Unità Operativa Riabilitazione SLA
- Dal 01 aprile 2023 è il Direttore Dipartimento Medicina Riabilitativa Neuromotoria degli Istituti Clinici Scientifici Maugeri IRCCS, Italia
- Dall’aprile 2022 è Aiuto Medico dell’ UO Riabilitazione Specialistica Neurologica/SLA presso Istituti Clinici Scientifici Maugeri IRCCS, Milano dove ricopre il ruolo di Responsabile dell’Unità SLA.
- Dal gennaio 2021 al maggio 2022 è stato il Direttore Scientifico di NEMO Lab srl di Milano, hub per progetti di innovazione tecnologica dedicato alle malattie neuromuscolari
- Dal 2019 al maggio 2022 è stato il Responsabile Scientifico del Registro Italiano SLA (Registro ITALS) nell’ambito
- dell’Associazione del Registro delle Malattie neuromuscolari che ha coinvolto diversi Centri SLA italiani
- Dal 2017 è membro della rete internazionale europea TRICALS dei centri impegnati nella conduzione di trial clinici sulla SLA
- Nel 2015 è stato membro della commissione medico-scientifica di scientifica dell’Associazione Italiana Sclerosi Laterale Amiotrofica (AISLA) per la stesura del documento sulle “Scelte di trattamento dei pazienti SLA”.
- Dal 2011 è membro del consorzio ITALSGEN per la conduzione di studi genetici nella SLA
- Dal 2011 è membro della commissione medico-scientifica dell’Associazione Italiana Sclerosi Laterale Amiotrofica (AISLA) e dal 2013 al 2022 ne ha ricoperto il ruolo di Medical Director
- Dal 2011 è membro del Gruppo di Studio delle Malattie del Motoneurone della Società Italiana di Neurologia (SIN)
- Dal 2009 è impegnato nello studio e presa in carico della Sindrome di Tarlov divenendo un punto di riferimento nazionale per la diagnosi e il management delle stesse.
- Dal 2009 al 2011 è stato Membro della Consulta Ministeriale per le Malattie Neuromuscolari ed ha partecipato alla stesura del documento finale che ha permesso di definire i modelli di presa in carico per le malattie neuromuscolari.
- Dal gennaio 2008 al marzo 2022 ha lavorato come neurologo responsabile Area SLA presso il Centro Clinico NEMO, Fondazione Serena Onlus, Milano. La sua attività clinica si è dedicata alla presa in carico dei pazienti con SLA dalla diagnosi fino alle fasi più avanzate. Ha partecipato alla organizzazione delle attività cliniche e alla definizione del modello multidisciplinare di presa in carico. E’ stato referente del Presidio della Rete per le Malattie Rare della Lombardia. E’ stato Principal Investigator di numerosi trial clinici nazionali e internazionali (fase IB, II e III) nella SLA e coordinatore di numerosi progetti di ricerca in ambito nazionale e internazionali nella SLA.
- Dal 2006 al 2007 ha lavorato presso lo come neurologo e borsista di ricerca presso il Dipartimento di Neurologia dell’Ospedale San Luca, IRCCS Istituto Auxologico Italiano, Università degli Studi di Milano dove ha partecipato nella definizione dei percorsi di presa in carico e nella conduzione di trial clinici nell’ambito della SLA
- Dal 2003 al 2006 ha frequentato il Dipartimento di Neurologia dell’Ospedale San Luca, IRCCS Istituto Auxologico Italiano, Università degli Studi di Milano per la conduzione di progetti di ricerca su aspetti genetici, analisi di biomarcatori (sangue, liquor e muscolo) e studio del fenotipo nella SLA.
Istruzione e Formazione
- Dal 30 giugno al 02 luglio 2021 Corso Avanzato Di Analisi Del Movimento In Clinica Riabilitativa presso Ospedale Bambino Gesù, Via Torre di Palidoro s.n.c., Fiumicino, Roma
- Nel 2006 ha conseguito il titolo di specializzazione in Neurologia (50/50 cum laude) presso l’Università degli studi di Palermo
- Nel 2001 ha conseguito la laurea in Medicina e Chirurgia (110/110 cum laude) presso l’Università degli studi di Palermo
Pubblicazioni
Spoladore D, Colombo V, Campanella V, Lunetta C, Mondellini M, Mahroo A, Cerri F, Sacco M. A Knowledge-based Decision Support System for recommending safe recipes to individuals with dysphagia. Comput Biol Med. 2024 Feb 19;171:108193. doi: 10.1016/j.compbio med.2024.108193. Epub ahead of print. PMID: 38387382.
Moreno-Martinez L, Macías-Redondo S, Strunk M, Guillén-Antonini MI, Lunetta C, Tarlarini C, Penco S, Calvo AC, Osta R, Schoorlemmer J. New Insights into Endogenous Retrovirus-K Transcripts in Amyotrophic Lateral Sclerosis. Int J Mol Sci. 2024 Jan 26;25(3):1549. doi: 10.3390/ijms25031549. PMID: 38338823; PMCID: PMC10855536.
Stoccoro A, Smith AR, Mosca L, Marocchi A, Gerardi F, Lunetta C, Lunnon K, Migliore L, Coppedè F. Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis. Epigenomics. 2024 Feb;16(4):203-214. doi: 10.2217/epi-2023- 0265. Epub 2024 Feb 5. PMID: 38312023.
Lombardo FL, Spila Alegiani S, Mayer F, Cipriani M, Lo Giudice M, Ludolph AC, McDermott CJ, Corcia P, Van Damme P, Van den Berg LH, Har diman O, Nicolini G, Vanacore N, Dickie B, Albanese A, Puopolo M; TUDCA-ALS Study Group. A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statis tical analysis plan of TUDCA-ALS trial. Trials. 2023 Dec 5;24(1):792. doi: 10.1186/s13063-023-07638-w. PMID: 38053196.
Sattin D, Parma C, Lunetta C, Zulueta A, Lanzone J, Giani L, Vassallo M, Picozzi M, Parati EA. An Overview of the Body Schema and Body Im age: Theoretical Models, Methodological Settings and Pitfalls for Rehabilitation of Persons with Neurological Disorders. Brain Sci. 2023 Oct 4;13(10):1410. doi: 10.3390/brainsci13101410. PMID: 37891779; PMCID: PMC10605253.
Pattee GL, Genge A, Couratier P, Lunetta C, Sobue G, Aoki M, Yoshino H, Jackson CE, Wymer J, Salah A, Nelson S. Oral Edaravone - Introducing a Flexible Treatment Option for Amyotrophic Lateral Sclerosis. Expert Rev Neurother. 2023 Jul-Dec;23(10):859-866. doi: 10.1080/14737175.2023.2251687. Epub 2023 Sep 12. PMID: 37646130.
Mandrioli J, D'Amico R, Zucchi E, De Biasi S, Banchelli F, Martinelli I, Simonini C, Lo Tartaro D, Vicini R, Fini N, Gianferrari G, Pinti M, Lunetta C, Gerardi F, Tarlarini C, Mazzini L, De Marchi F, Scognamiglio A, Sorarù G, Fortuna A, Lauria G, Bella ED, Caponnetto C, Meo G, Chio A, Calvo A, Cossarizza A. Randomized, double-blind, placebo-controlled trial of rapamycin in amyotrophic lateral sclerosis. Nat Commun. 2023 Aug 17;14(1):4970. doi: 10.1038/s41467-023-40734-8. PMID: 37591957; PMCID: PMC10435464.
Fortunato F, Bianchi F, Ricci G, Torri F, Gualandi F, Neri M, Farnè M, Giannini F, Malandrini A, Volpi N, Lopergolo D, Silani V, Ticozzi N, Verde F, Pareyson D, Fenu S, Bonanno S, Nigro V, Peduto C, D'Ambrosio P, Zeuli R, Zanobio M, Picillo E, Servidei S, Primiano G, Sancricca C, Sciacco M, Brusa R, Filosto M, Cotti Piccinelli S, Pegoraro E, Mongini T, Solero L, Gadaleta G, Brusa C, Minetti C, Bruno C, Panicucci C, Sansone VA, Lu
netta C, Zanolini A, Toscano A, Pugliese A, Nicocia G, Bertini E, Catteruccia M, Diodato D, Atalaia A, Evangelista T, Siciliano G, Ferlini A. Digital health and Clinical Patient Management System (CPMS) platform utility for data sharing of neuromuscular patients: the Italian EURO-NMD experience. Orphanet J Rare Dis. 2023 Jul 21;18(1):196. doi: 10.1186/s13023-023-02776-5. PMID: 37480080; PMCID: PMC10360326.
Berger A, Locatelli M, Arcila-Londono X, Hayat G, Olney N, Wymer J, Gwathmey K, Lunetta C, Heiman-Patterson T, Ajroud-Driss S, Macklin EA, Bind MA, Goslin K, Stuchiner T, Brown L, Bazan T, Regan T, Adamo A, Ferment V, Schroeder C, Somers M, Manousakis G, Faulconer K, Sinani E, Mirochnick J, Yu H, Sherman AV, Walk D; Pooled Resource Open-Access ALS Clinical Trials Consortium. The natural history of ALS: Baseline characteristics from a multicenter clinical cohort. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Jul 17:1-9. doi: 10.1080/21678421.2023.2232812. Epub ahead of print. PMID: 37461167.
Shefner JM, Musaro A, Ngo ST, Lunetta C, Steyn FJ, Robitaille R, De Carvalho M, Rutkove S, Ludolph AC, Dupuis L. Skeletal muscle in amyo trophic lateral sclerosis. Brain. 2023 Jun 16:awad202. doi: 10.1093/brain/awad202. Epub ahead of print. PMID: 37327376.
Aiello EN, Solca F, Greco LC, Torre S, Carelli L, Morelli C, Doretti A, Colombo E, Messina S, Pain D, Radici A, Lizio A, Casiraghi J, Cerri F, Woolley S, Murphy J, Tremolizzo L, Appollonio I, Verde F, Sansone VA, Lunetta C, Silani V, Ticozzi N, Poletti B. Equating norms between the ALS Cogni tive Behavioral Screen (ALS-CBS™) and the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in non-demented ALS patients. J Neurol. 2023 Aug;270(8):4090-4095. doi: 10.1007/s00415-023-11749-4. Epub 2023 May 5. PMID: 37147520.
Canosa A, Calvo A, Mora G, Moglia C, Brunetti M, Barberis M, Borghero G, Caponnetto C, Trojsi F, Spataro R, Volanti P, Simone IL, Salvi F, Lo gullo FO, Riva N, Tremolizzo L, Giannini F, Mandrioli J, Tanel R, Murru MR, Mandich P, Conforti FL, Zollino M, Sabatelli M, Tarlarini C, Lunetta C, Mazzini L, D'Alfonso S, Guy N, Meininger V, Clavelou P, Camu W, Chiò A, On Behalf Of Italsgen Consortium. The HFE p.H63D (p.His63Asp) Polymorphism Is a Modifier of ALS Outcome in Italian and French Patients with SOD1 Mutations. Biomedicines. 2023 Feb 24;11(3):704. doi: 10.3390/biomedicines11030704. PMID: 36979682; PMCID: PMC10044845.
Corcia P, Lunetta C, Vourc'h P, Pradat PF, Blasco H. Time for optimism in ALS. Eur J Neurol. 2023 Feb 11. doi: 10.1111/ene.15738. Epub ahead of print. PMID: 36773012.
Aiello EN, Solca F, Greco LC, La Tona A, Torre S, Carelli L, Morelli C, Doretti A, Colombo E, Messina S, Pain D, Radici A, Lizio A, Casiraghi J, Cerri F, Brugnera A, Compare A, Woolley S, Murphy J, Tremolizzo L, Appollonio I, Verde F, Sansone VA, Lunetta C, Silani V, Ticozzi N, Poletti B. Standardization of the Italian ALS-CBS™ Caregiver Behavioral Questionnaire. Front Psychol. 2023 Jan 20;13:1107001. doi: 10.3389/fpsyg.2022.1107001. PMID: 36743632; PMCID: PMC9896625.
Aiello EN, Greco LC, La Tona A, Solca F, Torre S, Carelli L, Pain D, Radici A, Lizio A, Casiraghi J, Cerri F, Brugnera A, Compare A, Woolley S, Mur phy J, Tremolizzo L, Appollonio I, Verde F, Silani V, Ticozzi N, Lunetta C, Sansone VA, Poletti B. Clinimetrics of the cognitive section of the Italian ALS Cognitive Behavioral Screen (ALS-CBS™). Neurol Sci. 2022 Dec 22. doi: 10.1007/s10072-022-06569-9. Epub ahead of print. PMID: 36547779.
Genge A, Pattee GL, Sobue G, Aoki M, Yoshino H, Couratier P, Lunetta C, Petri S, Selness D, Bidani S, Hirai M, Sakata T, Salah A, Apple S, Wamil A, Kalin A, Jackson CE. Oral edaravone demonstrated a favorable safety profile in patients with amyotrophic lateral sclerosis after 48 weeks of treatment. Muscle Nerve. 2023 Feb;67(2):124-129. doi: 10.1002/mus.27768. Epub 2022 Dec 28. PMID: 36504406.
Albanese A, Ludolph AC, McDermott CJ, Corcia P, Van Damme P, Van den Berg LH, Hardiman O, Rinaldi G, Vanacore N, Dickie B; TUDCA-ALS Study Group. Tauroursodeoxycholic acid in patients with amyotrophic lateral sclerosis: The TUDCA-ALS trial protocol. Front Neurol. 2022 Sep 27;13:1009113. doi: 10.3389/fneur.2022.1009113. PMID: 36237618; PMCID: PMC9552801.
Beghi E, Pupillo E, Bianchi E, Bonetto V, Luotti S, Pasetto L, Bendotti C, Tortarolo M, Sironi F, Camporeale L, Sherman AV, Paganoni S, Scogna miglio A, De Marchi F, Bongioanni P, Del Carratore R, Caponnetto C, Diamanti L, Martinelli D, Calvo A, Filosto M, Padovani A, Piccinelli SC, Ricci C, Dalla Giacoma S, De Angelis N, Inghilleri M, Spataro R, La Bella V, Logroscino G, Lunetta C, Tarlarini C, Mandrioli J, Martinelli I, Simo nini C, Zucchi E, Monsurrò MR, Ricciardi D, Trojsi F, Riva N, Filippi M, Simone IL, Sorarù G, Spera C, Florio L, Messina S, Russo M, Siciliano G, Conte A, Saddi MV, Carboni N, Mazzini L; RNS60-ALS Study Group. Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial. Eur J Neurol. 2023 Jan;30(1):69-86. doi: 10.1111/ene.15573. Epub 2022 Oct 7. PMID: 36148821.
Campisi L, Chizari S, Ho JSY, Gromova A, Arnold FJ, Mosca L, Mei X, Fstkchyan Y, Torre D, Beharry C, Garcia-Forn M, Jiménez-Alcázar M, Korobeynikov VA, Prazich J, Fayad ZA, Seldin MM, De Rubeis S, Bennett CL, Ostrow LW, Lunetta C, Squatrito M, Byun M, Shneider NA, Jiang N, La Spada AR, Marazzi I. Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature. 2022 Jun;606(7916):945-952. doi: 10.1038/s41586-022-04844-5. Epub 2022 Jun 22. Erratum in: Nature. 2022 Aug;608(7924):E34. PMID: 35732742.
Lunetta C, Lizio A, Cabona C, Gerardi F, Sansone VA, Corbo M, Scialò C, Angelucci E, Gualandi F, Marenco P, Grillo G, Cairoli R, Cesana C, Sac cardi R, Melazzini MG, Mancardi G, Caponnetto C. A phase I/IIa clinical trial of autologous hematopoietic stem cell transplantation in amyo trophic lateral sclerosis. J Neurol. 2022 Oct;269(10):5337-5346. doi: 10.1007/s00415-022-11185-w. Epub 2022 May 21. PMID: 35596795.
Tavazzi E, Daberdaku S, Zandonà A, Vasta R, Nefussy B, Lunetta C, Mora G, Mandrioli J, Grisan E, Tarlarini C, Calvo A, Moglia C, Drory V, Got kine M, Chiò A, Di Camillo B; Piemonte, Valle d’Aosta Register for ALS (PARALS), for the Emilia Romagna Registry for ALS (ERRALS). Predict ing functional impairment trajectories in amyotrophic lateral sclerosis: a probabilistic, multifactorial model of disease progression. J Neurol. 2022 Jul;269(7):3858-3878. doi: 10.1007/s00415-022-11022-0. Epub 2022 Mar 10. PMID: 35266043; PMCID: PMC9217910.
Kliest T, Van Eijk RPA, Al-Chalabi A, Albanese A, Andersen PM, Amador MDM, BrÅthen G, Brunaud-Danel V, Brylev L, Camu W, De Carvalho M, Cereda C, Cetin H, Chaverri D, Chiò A, Corcia P, Couratier P, De Marchi F, Desnuelle C, Van Es MA, Esteban J, Filosto M, GarcÍa Redondo A, Grosskreutz J, Hanemann CO, HolmØy T, HØyer H, Ingre C, Koritnik B, Kuzma-Kozakiewicz M, Lambert T, Leigh PN, Lunetta C, Mandrioli J, Mcdermott CJ, Meyer T, Mora JS, Petri S, Povedano M, Reviers E, Riva N, Roes KCB, Rubio MÁ, Salachas F, Sarafov S, SorarÙ G, Stevic Z, Sven strup K, MØller AT, Turner MR, Van Damme P, Van Leeuwen LAG, Varona L, VÁzquez Costa JF, Weber M, Hardiman O, Van Den Berg LH. Clini cal trials in pediatric ALS: a TRICALS feasibility study. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Nov;23(7-8):481-488. doi: 10.1080/21678421.2021.2024856. Epub 2022 Feb 16. PMID: 35172656; PMCID: PMC9662181.
Riva N, Gentile F, Cerri F, Gallia F, Podini P, Dina G, Falzone YM, Fazio R, Lunetta C, Calvo A, Logroscino G, Lauria G, Corbo M, Iannaccone S, Chiò A, Lazzerini A, Nobile-Orazio E, Filippi M, Quattrini A. Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis. Brain. 2022 Mar 29;145(1):276-284. doi: 10.1093/brain/awab285. PMID: 35076694; PMCID: PMC8967102.
Pugliese R, Sala R, Regondi S, Beltrami B, Lunetta C. Emerging technologies for management of patients with amyotrophic lateral sclerosis: from telehealth to assistive robotics and neural interfaces. J Neurol. 2022 Jun;269(6):2910-2921. doi: 10.1007/s00415-022-10971-w. Epub 2022 Jan 21. PMID: 35059816; PMCID: PMC8776511.
Ami D, Duse A, Mereghetti P, Cozza F, Ambrosio F, Ponzini E, Grandori R, Lunetta C, Tavazzi S, Pezzoli F, Natalello A. Tear-Based Vibrational Spectroscopy Applied to Amyotrophic Lateral Sclerosis. Anal Chem. 2021 Dec 28;93(51):16995-17002. doi: 10.1021/acs.analchem.1c02546. Epub 2021 Dec 14. PMID: 34905686; PMCID: PMC8717331.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra HJ, Bakker OB, Deelen P, Shireby G, Hannon E, Moisse M, Baird D, Restuadi R, Dolzhenko E, Dekker AM, Gawor K, Westeneng HJ, Tazelaar GHP, van Eijk KR, Kooyman M, Byrne RP, Doherty M, Heverin M, Al Khleifat A, Iacoangeli A, Shatunov A, Ticozzi N, Cooper-Knock J, Smith BN, Gromicho M, Chandran S, Pal S, Morri son KE, Shaw PJ, Hardy J, Orrell RW, Sendtner M, Meyer T, Başak N, van der Kooi AJ, Ratti A, Fogh I, Gellera C, Lauria G, Corti S, Cereda C, Sproviero D, D'Alfonso S, Sorarù G, Siciliano G, Filosto M, Padovani A, Chiò A, Calvo A, Moglia C, Brunetti M, Canosa A, Grassano M, Beghi E, Pupillo E, Logroscino G, Nefussy B, Osmanovic A, Nordin A, Lerner Y, Zabari M, Gotkine M, Baloh RH, Bell S, Vourc'h P, Corcia P, Couratier P, Millecamps S, Meininger V, Salachas F, Mora Pardina JS, Assialioui A, Rojas-García R, Dion PA, Ross JP, Ludolph AC, Weishaupt JH, Brenner D, Freischmidt A, Bensimon G, Brice A, Durr A, Payan CAM, Saker-Delye S, Wood NW, Topp S, Rademakers R, Tittmann L, Lieb W, Franke A, Ripke S, Braun A, Kraft J, Whiteman DC, Olsen CM, Uitterlinden AG, Hofman A, Rietschel M, Cichon S, Nöthen MM, Amouyel P; SLALOM Con sortium; PARALS Consortium; SLAGEN Consortium; SLAP Consortium; Traynor BJ, Singleton AB, Mitne Neto M, Cauchi RJ, Ophoff RA, Wiedau-Pazos M, Lomen-Hoerth C, van Deerlin VM, Grosskreutz J, Roediger A, Gaur N, Jörk A, Barthel T, Theele E, Ilse B, Stubendorff B, Witte OW, Steinbach R, Hübner CA, Graff C, Brylev L, Fominykh V, Demeshonok V, Ataulina A, Rogelj B, Koritnik B, Zidar J, Ravnik-Glavač M, Glavač D, Stević Z, Drory V, Povedano M, Blair IP, Kiernan MC, Benyamin B, Henderson RD, Furlong S, Mathers S, McCombe PA, Needham M, Ngo ST, Nicholson GA, Pamphlett R, Rowe DB, Steyn FJ, Williams KL, Mather KA, Sachdev PS, Henders AK, Wallace L, de Carvalho M, Pinto S, Petri S, Weber M, Rouleau GA, Silani V, Curtis CJ, Breen G, Glass JD, Brown RH Jr, Landers JE, Shaw CE, Andersen PM, Groen EJN, van Es MA, Paster kamp RJ, Fan D, Garton FC, McRae AF, Davey Smith G, Gaunt TR, Eberle MA, Mill J, McLaughlin RL, Hardiman O, Kenna KP, Wray NR, Tsai E, Runz H, Franke L, Al-Chalabi A, Van Damme P, van den Berg LH, Veldink JH. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet. 2021 Dec;53(12):1636-1648. doi: 10.1038/s41588-021-00973-1. Epub 2021 Dec 6. Erratum in: Nat Genet. 2022 Mar;54(3):361. PMID: 34873335; PMCID: PMC8648564.
Diamanti L, Borrelli P, Dubbioso R, Capasso M, Morelli C, Lunetta C, Petrucci A, Mora G, Volanti P, Inghilleri M, Tremolizzo L, Mandrioli J, Maz zini L, Vedovello M, Siciliano G, Filosto M, Matà S, Montomoli C; DYALS Study Group. Validation of the DYALS (dysphagia in amyotrophic lat eral sclerosis) questionnaire for the evaluation of dysphagia in ALS patients. Neurol Sci. 2022 May;43(5):3195-3200. doi:10.1007/s10072- 021-05775-1. Epub 2021 Dec 1. PMID: 34853898.
Carraro E, Casiraghi JL, Bobba B, Lizio A, Cardella C, Albamonte E, Lunetta C, Pozzi S, Sansone VA. Wheelchair hockey improves quality of life in people with neuromuscular disease. PM R. 2022 Dec;14(12):1446-1453. doi: 10.1002/pmrj.12736. Epub 2022 Jan 11. PMID: 34773450. Corcia P, Lunetta C, Couratier P, Vourc'h P, Gromicho M, Desnuelle C, Soriani MH, Pinto S, de Carvalho M. Reply to the letter from Gazulla et al. Eur J Neurol. 2022 Jan;29(1):e3-e4. doi: 10.1111/ene.15134. Epub 2021 Oct 18. PMID: 34624147.
Ginocchio D, Ninfa A, Pizzorni N, Lunetta C, Sansone VA, Schindler A. Cross-Cultural Adaptation and Validation of the Italian Version of the Dysphagia Handicap Index (I-DHI). Dysphagia. 2022 Oct;37(5):1120-1136. doi: 10.1007/s00455-021-10369-2. Epub 2021 Sep 28. PMID: 34581857; PMCID: PMC9463219.
Poletti B, Solca F, Carelli L, Diena A, Colombo E, Torre S, Maranzano A, Greco L, Cozza F, Lizio A, Ferrucci R, Girotti F, Verde F, Morelli C, Lu netta C, Silani V, Ticozzi N. Association of Clinically Evident Eye Movement Abnormalities With Motor and Cognitive Features in Patients With Motor Neuron Disorders. Neurology. 2021 Nov 2;97(18):e1835-e1846. doi: 10.1212/WNL.0000000000012774. Epub 2021 Sep 9. PMID: 34504031.
Johnson JO, Chia R, Miller DE, Li R, Kumaran R, Abramzon Y, Alahmady N, Renton AE, Topp SD, Gibbs JR, Cookson MR, Sabir MS, Dalgard CL, Troakes C, Jones AR, Shatunov A, Iacoangeli A, Al Khleifat A, Ticozzi N, Silani V, Gellera C, Blair IP, Dobson-Stone C, Kwok JB, Bonkowski ES, Palvadeau R, Tienari PJ, Morrison KE, Shaw PJ, Al-Chalabi A, Brown RH Jr, Calvo A, Mora G, Al-Saif H, Gotkine M, Leigh F, Chang IJ, Perlman SJ, Glass I, Scott AI, Shaw CE, Basak AN, Landers JE, Chiò A, Crawford TO, Smith BN, Traynor BJ; FALS Sequencing Consortium; American Genome Center; International ALS Genomics Consortium; and ITALSGEN Consortium; Smith BN, Ticozzi N, Fallini C, Gkazi AS, Topp SD, Scotter EL, Kenna KP, Keagle P, Tiloca C, Vance C, Troakes C, Colombrita C, King A, Pensato V, Castellotti B, Baas F, Ten Asbroek ALMA, McKenna Yasek D, McLaughlin RL, Polak M, Asress S, Esteban-Pérez J, Stevic Z, D'Alfonso S, Mazzini L, Comi GP, Del Bo R, Ceroni M, Gagliardi S, Querin
G, Bertolin C, van Rheenen W, Rademakers R, van Blitterswijk M, Lauria G, Duga S, Corti S, Cereda C, Corrado L, Sorarù G, Williams KL, Nichol son GA, Blair IP, Leblond-Manry C, Rouleau GA, Hardiman O, Morrison KE, Veldink JH, van den Berg LH, Al-Chalabi A, Pall H, Shaw PJ, Turner MR, Talbot K, Taroni F, García-Redondo A, Wu Z, Glass JD, Gellera C, Ratti A, Brown RH Jr, Silani V, Shaw CE, Landers JE, Dalgard CL, Adeleye A, Soltis AR, Alba C, Viollet C, Bacikova D, Hupalo DN, Sukumar G, Pollard HB, Wilkerson MD, Martinez EM, Abramzon Y, Ahmed S, Arepalli S,
Baloh RH, Bowser R, Brady CB, Brice A, Broach J, Campbell RH, Camu W, Chia R, Cooper-Knock J, Ding J, Drepper C, Drory VE, Dunckley TL, Eicher JD, England BK, Faghri F, Feldman E, Floeter MK, Fratta P, Geiger JT, Gerhard G, Gibbs JR, Gibson SB, Glass JD, Hardy J, Harms MB, Heiman-Patterson TD, Hernandez DG, Jansson L, Kirby J, Kowall NW, Laaksovirta H, Landeck N, Landi F, Le Ber I, Lumbroso S, MacGowan DJL, Maragakis NJ, Mora G, Mouzat K, Murphy NA, Myllykangas L, Nalls MA, Orrell RW, Ostrow LW, Pamphlett R, Pickering-Brown S, Pioro EP, Pletnikova O, Pliner HA, Pulst SM, Ravits JM, Renton AE, Rivera A, Robberecht W, Rogaeva E, Rollinson S, Rothstein JD, Scholz SW, Sendtner M, Shaw PJ, Sidle KC, Simmons Z, Singleton AB, Smith N, Stone DJ, Tienari PJ, Troncoso JC, Valori M, Van Damme P, Van Deerlin VM, Van Den Bosch L, Zinman L, Landers JE, Chiò A, Traynor BJ, Angelocola SM, Ausiello FP, Barberis M, Bartolomei I, Battistini S, Bersano E, Bisogni G, Borghero G, Brunetti M, Cabona C, Calvo A, Canale F, Canosa A, Cantisani TA, Capasso M, Caponnetto C, Cardinali P, Carrera P, Casale F, Chiò A, Colletti T, Conforti FL, Conte A, Conti E, Corbo M, Cuccu S, Dalla Bella E, D'Errico E, DeMarco G, Dubbioso R, Ferrarese C, Ferraro PM, Filippi M, Fini N, Floris G, Fuda G, Gallone S, Gianferrari G, Giannini F, Grassano M, Greco L, Iazzolino B, Introna A, La Bella V, Lattante S, Lauria G, Li guori R, Logroscino G, Logullo FO, Lunetta C, Mandich P, Mandrioli J, Manera U, Manganelli F, Marangi G, Marinou K, Marrosu MG, Martinelli I, Messina S, Moglia C, Mora G, Mosca L, Murru MR, Origone P, Passaniti C, Petrelli C, Petrucci A, Pozzi S, Pugliatti M, Quattrini A, Ricci C, Riolo G, Riva N, Russo M, Sabatelli M, Salamone P, Salivetto M, Salvi F, Santarelli M, Sbaiz L, Sideri R, Simone I, Simonini C, Spataro R, Tanel R, Tedeschi G, Ticca A, Torriello A, Tranquilli S, Tremolizzo L, Trojsi F, Vasta R, Vacchiano V, Vita G, Volanti P, Zollino M, Zucchi E. Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis. JAMA Neurol. 2021 Oct 1;78(10):1236-1248. doi: 10.1001/jamaneu rol.2021.2598. PMID: 34459874; PMCID: PMC8406220.
Greco LC, Lizio A, Casiraghi J, Sansone VA, Tremolizzo L, Riva N, Solca F, Torre S, Ticozzi N, Filippi M, Silani V, Poletti B, Lunetta C. A prelimi nary comparison between ECAS and ALS-CBS in classifying cognitive-behavioural phenotypes in a cohort of non-demented amyotrophic lateral sclerosis patients. J Neurol. 2022 Apr;269(4):1899-1904. doi: 10.1007/s00415-021-10753-w. Epub 2021 Aug 19. PMID: 34410493.
Pasetto L, Callegaro S, Corbelli A, Fiordaliso F, Ferrara D, Brunelli L, Sestito G, Pastorelli R, Bianchi E, Cretich M, Chiari M, Potrich C, Moglia C, Corbo M, Sorarù G, Lunetta C, Calvo A, Chiò A, Mora G, Pennuto M, Quattrone A, Rinaldi F, D'Agostino VG, Basso M, Bonetto V. Decoding di stinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis. Mol Neurodegener. 2021 Aug 10;16(1):52. doi: 10.1186/s13024-021-00470-3. PMID: 34376243; PMCID: PMC8353748.
Cattaneo M, Jesus P, Lizio A, Fayemendy P, Guanziroli N, Corradi E, Sansone V, Leocani L, Filippi M, Riva N, Corcia P, Couratier P, Lunetta C. The hypometabolic state: a good predictor of a better prognosis in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2022 Jan;93(1):41-47. doi: 10.1136/jnnp-2021-326184. Epub 2021 Aug 5. PMID: 34353859.
Corcia P, Lunetta C, Couratier P, Vourc'h P, Gromicho M, Desnuelle C, Soriani MH, Pinto S, de Carvalho M. Familial clustering of primary lat eral sclerosis and amyotrophic lateral sclerosis: Supplementary evidence for a continuum. Eur J Neurol. 2021 Aug;28(8):2780-2783. doi: 10.1111/ene.14960. Epub 2021 Jun 23. PMID: 34110677.
Barp A, Lizio A, Gerardi F, Tarlarini C, Mauro L, Sansone VA, Lunetta C. Neurophysiological indices in amyotrophic lateral sclerosis correlate with functional outcome measures, staging and disease progression. Clin Neurophysiol. 2021 Jul;132(7):1564-1571. doi: 10.1016/j.clinph.2021.02.394. Epub 2021 Apr 7. PMID: 34023632.
Dalla Bella E, Bersano E, Antonini G, Borghero G, Capasso M, Caponnetto C, Chiò A, Corbo M, Filosto M, Giannini F, Spataro R, Lunetta C, Man drioli J, Messina S, Monsurrò MR, Mora G, Riva N, Rizzi R, Siciliano G, Silani V, Simone I, Sorarù G, Tugnoli V, Verriello L, Volanti P, Furlan R, Nolan JM, Abgueguen E, Tramacere I, Lauria G. The unfolded protein response in amyotrophic later sclerosis: results of a phase 2 trial. Brain. 2021 Oct 22;144(9):2635-2647. doi: 10.1093/brain/awab167. PMID: 33905493; PMCID: PMC8557337.
Moreno-García L, Miana-Mena FJ, Moreno-Martínez L, de la Torre M, Lunetta C, Tarlarini C, Zaragoza P, Calvo AC, Osta R. Inflammasome in ALS Skeletal Muscle: <i>NLRP3</i> as a Potential Biomarker. Int J Mol Sci. 2021 Mar 3;22(5):2523. doi: 10.3390/ijms22052523. PMID: 33802349; PMCID: PMC7959138.
Storti B, Diamanti S, Tremolizzo L, Riva N, Lunetta C, Filippi M, Ferrarese C, Appollonio I. ALS Mimics due to Affection of the Cervical Spine: From Common Compressive Myelopathy to Rare CSF Epidural Collection. Case Rep Neurol. 2021 Mar 4;13(1):145-156. doi: 10.1159/000512810. PMID: 33790773; PMCID: PMC7989791.
Barp A, Velardo D, Ciscato P, Sansone VA, Lunetta C. Anti-HMGCR myopathy misdiagnosed as motor neuron disease and complicated with COVID-19 infection. Neurol Sci. 2021 May;42(5):1679-1682. doi: 10.1007/s10072-021-05146-w. Epub 2021 Mar 1. PMID: 33646438; PMCID: PMC7917165.
Lanteri P, Meola I, Canosa A, De Marco G, Lomartire A, Rinaudo MT, Albamonte E, Sansone VA, Lunetta C, Manera U, Vasta R, Moglia C, Calvo A, Origone P, Chiò A, Mandich P. The heterozygous deletion c.1509_1510delAG in exon 14 of FUS causes an aggressive childhood-onset ALS with cognitive impairment. Neurobiol Aging. 2021 Jul;103:130.e1-130.e7. doi: 10.1016/j.neurobiolaging.2021.01.029. Epub 2021 Feb 3. PMID: 33637330.
Cozza F, Lizio A, Greco LC, Bona S, Donvito G, Carraro E, Tavazzi S, Ticozzi N, Poletti B, Sansone VA, Lunetta C. Ocular Involvement Occurs Frequently at All Stages of Amyotrophic Lateral Sclerosis: Preliminary Experience in a Large Italian Cohort. J Clin Neurol. 2021 Jan;17(1):96- 105. doi: 10.3988/jcn.2021.17.1.96. PMID: 33480204; PMCID: PMC7840315.
Conti E, Sala G, Diamanti S, Casati M, Lunetta C, Gerardi F, Tarlarini C, Mosca L, Riva N, Falzone Y, Filippi M, Appollonio I, Ferrarese C, Tremo lizzo L. Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis. Sci Rep. 2021 Jan 21;11(1):1978. doi: 10.1038/s41598-021-81599-5. PMID: 33479441; PMCID: PMC7820419.
Barp A, Ada Sansone V, Lunetta C. Challenges in diagnosis of motor neuron disease: A case series of ALS mimic syndromes. Rev Neurol (Paris). 2021 Jun;177(6):699-706. doi: 10.1016/j.neurol.2020.08.010. Epub 2020 Dec 31. PMID: 33390263.
Crespi C, Santi GC, Dodich A, Lupo F, Greco LC, Piccoli T, Lunetta C, Cerami C. Unraveling Moral Reasoning in Amyotrophic Lateral Sclerosis: How Emotional Detachment Modifies Moral Judgment. Front Psychol. 2020 Aug 21;11:2083. doi: 10.3389/fpsyg.2020.02083. PMID: 32973626; PMCID: PMC7471658.
Russo M, Lunetta C, Zuccarino R, Vita GL, Sframeli M, Lizio A, La Foresta S, Faraone C, Sansone VA, Vita G, Messina S. The 6-min walk test as a new outcome measure in Amyotrophic lateral sclerosis. Sci Rep. 2020 Sep 23;10(1):15580. doi: 10.1038/s41598-020-72578-3. PMID: 32968168; PMCID: PMC7511965.
Stoccoro A, Smith AR, Mosca L, Marocchi A, Gerardi F, Lunetta C, Cereda C, Gagliardi S, Lunnon K, Migliore L, Coppedè F. Reduced mitochon drial D-loop methylation levels in sporadic amyotrophic lateral sclerosis. Clin Epigenetics. 2020 Sep 11;12(1):137. doi: 10.1186/s13148-020- 00933-2. PMID: 32917270; PMCID: PMC7488473.
Tondo G, Iaccarino L, Cerami C, Vanoli GE, Presotto L, Masiello V, Coliva A, Salvi F, Bartolomei I, Mosca L, Lunetta C, Perani D. <sup>11</sup> C-PK11195 PET-based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2020 Sep;7(9):1513-1523. doi: 10.1002/acn3.51112. Epub 2020 Aug 6. PMID: 32762033; PMCID: PMC7480909.
Barp A, Carraro E, Albamonte E, Salmin F, Lunetta C, Comi GP, Messina C, Albano D, Chianca V, Sconfienza LM, Mercuri EM, Sansone VA. Mus cle MRI in two SMA patients on nusinersen treatment: A two years follow-up. J Neurol Sci. 2020 Oct 15;417:117067. doi: 10.1016/j.jns.2020.117067. Epub 2020 Jul 29. PMID: 32745721; PMCID: PMC7388822.
Russo M, Bonanno C, Profazio C, La Foresta S, Faraone C, Lizio A, Vita GL, Sframeli M, Aricò I, Ruggeri P, Toscano A, Vita G, Lunetta C, Messina S. Which are the factors influencing NIV adaptation and tolerance in ALS patients? Neurol Sci. 2021 Mar;42(3):1023-1029. doi: 10.1007/s10072-020-04624-x. Epub 2020 Jul 24. PMID: 32710206.
Schito P, Ceccardi G, Calvo A, Falzone YM, Moglia C, Lunetta C, Marinou K, Ticozzi N, Scialo C, Sorarù G, Trojsi F, Conte A, Tortelli R, Russo M, Zucchi E, Pozzi L, Domi T, Carrera P, Agosta F, Quattrini A, Fazio R, Chiò A, Sansone VA, Mora G, Silani V, Volanti P, Caponnetto C, Querin G, Tedeschi G, Sabatelli M, Logroscino G, Messina S, Mandrioli J, Riva N, Filippi M. Clinical features and outcomes of the flail arm and flail leg and pure lower motor neuron MND variants: a multicentre Italian study. J Neurol Neurosurg Psychiatry. 2020 Sep;91(9):1001-1003. doi: 10.1136/jnnp-2020-323542. Epub 2020 Jul 10. PMID: 32651246.
Lunetta C, Lizio A, Gerardi F, Tarlarini C, Filippi M, Riva N, Tremolizzo L, Diamanti S, Dellanoce CC, Mosca L, Sansone VA, Campolo J. Urinary neopterin, a new marker of the neuroinflammatory status in amyotrophic lateral sclerosis. J Neurol. 2020 Dec;267(12):3609-3616. doi: 10.1007/s00415-020-10047-7. Epub 2020 Jul 8. PMID: 32638112.
Bendotti C, Bonetto V, Pupillo E, Logroscino G, Al-Chalabi A, Lunetta C, Riva N, Mora G, Lauria G, Weishaupt JH, Agosta F, Malaspina A, Basso M, Greensmith L, Van Den Bosch L, Ratti A, Corbo M, Hardiman O, Chiò A, Silani V, Beghi E. Focus on the heterogeneity of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Nov;21(7-8):485-495. doi: 10.1080/21678421.2020.1779298. Epub 2020 Jun 25. PMID: 32583689.
Lunetta C, Moglia C, Lizio A, Caponnetto C, Dubbioso R, Giannini F, Matà S, Mazzini L, Sabatelli M, Siciliano G, Simone IL, Sorarù G, Toriello A, Trojsi F, Vedovello M, D'Ovidio F, Filippi M, Calvo A; and EDARAVALS Study Group. The Italian multicenter experience with edaravone in amyotrophic lateral sclerosis. J Neurol. 2020 Nov;267(11):3258-3267. doi: 10.1007/s00415-020-09993-z. Epub 2020 Jun 17. PMID: 32556567.
Barp A, Gerardi F, Lizio A, Sansone VA, Lunetta C. Emerging Drugs for the Treatment of Amyotrophic Lateral Sclerosis: A Focus on Recent Phase 2 Trials. Expert Opin Emerg Drugs. 2020 Jun;25(2):145-164. doi:
10.1080/14728214.2020.1769067. Epub 2020 May 27. PMID: 32456491.
Poletti B, Carelli L, Lunetta C, Ticozzi N, Silani V. Advance care planning and mental capacity in ALS: a current challenge for an unsolved mat ter. Neurol Sci. 2020 Oct;41(10):2997-2998. doi: 10.1007/s10072-020-04462-x. Epub 2020 May 20. PMID: 32435995.
Schijven D, Stevelink R, McCormack M, van Rheenen W, Luykx JJ, Koeleman BPC, Veldink JH; Project MinE ALS GWAS Consortium; Interna tional League Against Epilepsy Consortium on Complex Epilepsies. Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy. Neurobiol Aging. 2020 Aug;92:153.e1-153.e5. doi: 10.1016/j.neurobiolaging.2020.04.011. Epub 2020 Apr 18. PMID: 32409253; PMCID: PMC7818383.
Scarlino S, Domi T, Pozzi L, Romano A, Pipitone GB, Falzone YM, Mosca L, Penco S, Lunetta C, Sansone V, Tremolizzo L, Fazio R, Agosta F, Filippi M, Carrera P, Riva N, Quattrini A. Burden of Rare Variants in ALS and Axonal Hereditary Neuropathy Genes Influence Survival in ALS: Insights from a Next Generation Sequencing Study of an Italian ALS Cohort. Int J Mol Sci. 2020 May 8;21(9):3346. doi: 10.3390/ijms21093346. PMID: 32397312; PMCID: PMC7246633.
Loffreda A, Nizzardo M, Arosio A, Ruepp MD, Calogero RA, Volinia S, Galasso M, Bendotti C, Ferrarese C, Lunetta C, Rizzuti M, Ronchi AE, Mühlemann O, Tremolizzo L, Corti S, Barabino SML. miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis. Prog Neurobiol. 2020 Jul;190:101803. doi: 10.1016/j.pneurobio.2020.101803. Epub 2020 Apr 24. PMID: 32335272.
De Mattia E, Lizio A, Falcier E, Sannicolò G, Gualandris M, Rossi G, Zanolini A, Pozzi S, Messina S, Sframeli M, Lunetta C, Rao F, Sansone VA. Screening for early symptoms of respiratory involvement in myotonic dystrophy type 1 using the Respicheck questionnaire. Neuromuscul Disord. 2020 Apr;30(4):301-309. doi: 10.1016/j.nmd.2020.02.014. Epub 2020 Feb 29. PMID: 32305258.
Salamone P, Fuda G, Casale F, Marrali G, Lunetta C, Caponnetto C, Mazzini L, La Bella V, Mandrioli J, Simone IL, Moglia C, Calvo A, Tarella C, Chio A; STEMALS-II Study Group. G-CSF (filgrastim) treatment for amyotrophic lateral sclerosis: protocol for a phase II randomised, double blind, placebo-controlled, parallel group, multicentre clinical study (STEMALS-II trial). BMJ Open. 2020 Mar 24;10(3):e034049. doi: 10.1136/bmjopen-2019-034049. PMID: 32209625; PMCID: PMC7202695.
Luotti S, Pasetto L, Porcu L, Torri V, Elezgarai SR, Pantalone S, Filareti M, Corbo M, Lunetta C, Mora G, Bonetto V. Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis. Neurobiol Dis. 2020 Jun;139:104815. doi: 10.1016/j.nbd.2020.104815. Epub 2020 Feb 20. PMID: 32087285.
De Schaepdryver M, Lunetta C, Tarlarini C, Mosca L, Chio A, Van Damme P, Poesen K. Neurofilament light chain and C reactive protein ex plored as predictors of survival in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2020 Apr;91(4):436-437. doi: 10.1136/jnnp 2019-322309. Epub 2020 Feb 6. PMID: 32029541.
Tremolizzo L, Lizio A, Santangelo G, Diamanti S, Lunetta C, Gerardi F, Messina S, La Foresta S, Riva N, Falzone Y, Filippi M, Woolley SC, San sone VA, Siciliano M, Ferrarese C, Appollonio I; ALS-CBS Italian Study Group. ALS Cognitive Behavioral Screen (ALS-CBS): normative values for the Italian population and clinical usability. Neurol Sci. 2020 Apr;41(4):835-841. doi: 10.1007/s10072-019-04154-1. Epub 2019 Dec 5. PMID: 31807998.
Bona S, Donvito G, Cozza F, Malberti I, Vaccari P, Lizio A, Greco L, Carraro E, Sansone VA, Lunetta C. The development of an augmented reality device for the autonomous management of the electric bed and the electric wheelchair for patients with amyotrophic lateral sclerosis: a pilot study. Disabil Rehabil Assist Technol. 2021 Jul;16(5):513-519. doi: 10.1080/17483107.2019.1683237. Epub 2019 Nov 5. PMID: 31686552.
Arosio A, Cristofani R, Pansarasa O, Crippa V, Riva C, Sirtori R, Rodriguez- Menendez V, Riva N, Gerardi F, Lunetta C, Cereda C, Poletti A, Fer rarese C, Tremolizzo L, Sala G. HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accu mulation. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Feb;21(1-2):51-62. doi: 10.1080/21678421.2019.1672749. Epub 2019 Oct 30. PMID: 31663379.
Pirola A, De Mattia E, Lizio A, Sannicolò G, Carraro E, Rao F, Sansone V, Lunetta C. The prognostic value of spirometric tests in Amyotrophic Lateral Sclerosis patients. Clin Neurol Neurosurg. 2019 Sep;184:105456. doi: 10.1016/j.clineuro.2019.105456. Epub 2019 Jul 29. PMID: 31382080.
Sala G, Arosio A, Conti E, Beretta S, Lunetta C, Riva N, Ferrarese C, Tremolizzo L. Riluzole Selective Antioxidant Effects in Cell Models Expres sing Amyotrophic Lateral Sclerosis Endophenotypes. Clin Psychopharmacol Neurosci. 2019 Aug 31;17(3):438-442. doi: 10.9758/cpn.2019.17.3.438. PMID: 31352711; PMCID: PMC6705104.
Gentile F, Scarlino S, Falzone YM, Lunetta C, Tremolizzo L, Quattrini A, Riva N. The Peripheral Nervous System in Amyotrophic Lateral Sclero sis: Opportunities for Translational Research. Front Neurosci. 2019 Jun 25;13:601. doi: 10.3389/fnins.2019.00601. PMID: 31293369; PMCID: PMC6603245.
Mora JS, Genge A, Chio A, Estol CJ, Chaverri D, Hernández M, Marín S, Mascias J, Rodriguez GE, Povedano M, Paipa A, Dominguez R, Gamez J, Salvado M, Lunetta C, Ballario C, Riva N, Mandrioli J, Moussy A, Kinet JP, Auclair C, Dubreuil P, Arnold V, Mansfield CD, Hermine O; AB10015 STUDY GROUP. Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial. Amyo troph Lateral Scler Frontotemporal Degener. 2020 Feb;21(1-2):5-14. doi: 10.1080/21678421.2019.1632346. Epub 2019 Jul 7. PMID: 31280619.
Trojsi F, Siciliano M, Femiano C, Santangelo G, Lunetta C, Calvo A, Moglia C, Marinou K, Ticozzi N, Ferro C, Scialò C, Sorarù G, Conte A, Falzone YM, Tortelli R, Russo M, Sansone VA, Chiò A, Mora G, Silani V, Volanti P, Caponnetto C, Querin G, Sabatelli M, Riva N, Logroscino G, Messina S, Fasano A, Monsurrò MR, Tedeschi G, Mandrioli J. Comparative Analysis of <i>C9orf72</i> and Sporadic Disease in a Large Multicenter ALS Population: The Effect of Male Sex on Survival of <i>C9orf72</i> Positive Patients. Front Neurosci. 2019 May 17;13:485. doi: 10.3389/fnins.2019.00485. PMID: 31156370; PMCID: PMC6534038.
Shefner JM, Cudkowicz ME, Hardiman O, Cockcroft BM, Lee JH, Malik FI, Meng L, Rudnicki SA, Wolff AA, Andrews JA; VITALITY-ALS Study Group. A phase III trial of <i>tirasemtiv</i> as a potential treatment for amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotem poral Degener. 2019;0(0):1-11. doi: 10.1080/21678421.2019.1612922. Erratum in: Amyotroph Lateral Scler Frontotemporal Degener. 2019 Jul 14;:1. PMID: 31081694.
Calvo AC, Cibreiro GA, Merino PT, Roy JF, Galiana A, Rufián AJ, Cano JM, Martín MA, Moreno L, Larrodé P, Vázquez PC, Galán L, Mora J, Muñoz Blanco JL, Muñoz MJ, Zaragoza P, Pegoraro E, Sorarù G, Mora M, Lunetta C, Penco S, Tarlarini C, Esteban J, Osta R, Redondo AG. Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis. Aging Dis. 2019 Apr 1;10(2):278-292. doi: 10.14336/AD.2018.0917. PMID: 31011479; PMCID: PMC6457048.
Lattante S, Doronzio PN, Marangi G, Conte A, Bisogni G, Bernardo D, Russo T, Lamberti D, Patrizi S, Apollo FP, Lunetta C, Scarlino S, Pozzi L, Zollino M, Riva N, Sabatelli M. Coexistence of variants in TBK1 and in other ALS-related genes elucidates an oligogenic model of pathogenesis in sporadic ALS. Neurobiol Aging. 2019 Dec;84:239.e9-239.e14. doi: 10.1016/j.neurobiolaging.2019.03.010. Epub 2019 Mar 27. PMID: 31000212.
Spinelli EG, Agosta F, Ferraro PM, Querin G, Riva N, Bertolin C, Martinelli I, Lunetta C, Fontana A, Sorarù G, Filippi M. Brain MRI shows white matter sparing in Kennedy's disease and slow-progressing lower motor neuron disease. Hum Brain Mapp. 2019 Jul;40(10):3102-3112. doi: 10.1002/hbm.24583. Epub 2019 Mar 28. PMID: 30924230; PMCID: PMC6865482.
Visser AE, D'Ovidio F, Peters S, Vermeulen RC, Beghi E, Chiò A, Veldink JH, Logroscino G, Hardiman O, van den Berg LH; Euro-MOTOR consor tium. Multicentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk. J Neurol Neurosurg Psychiatry. 2019 Aug;90(8):854-860. doi: 10.1136/jnnp-2018-319779. Epub 2019 Mar 8. PMID: 30850472.
Conti E, Grana D, Stefanoni G, Corsini A, Botta M, Magni P, Aliprandi A, Lunetta C, Appollonio I, Ferrarese C, Tremolizzo L. Irisin and BDNF serum levels and behavioral disturbances in Alzheimer's disease. Neurol Sci. 2019 Jun;40(6):1145-1150. doi: 10.1007/s10072-019-03781-y. Epub 2019 Feb 27. PMID: 30810826.
Bandres-Ciga S, Noyce AJ, Hemani G, Nicolas A, Calvo A, Mora G; ITALSGEN Consortium; International ALS Genomics Consortium; Tienari PJ, Stone DJ, Nalls MA, Singleton AB, Chiò A, Traynor BJ. Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis. Ann Neurol. 2019 Apr;85(4):470-481. doi: 10.1002/ana.25431. Epub 2019 Mar 13. Erratum in: Ann Neurol. 2020 Jun;87(6):991-992. PMID: 30723964; PMCID: PMC6450729.
Riva N, Mora G, Sorarù G, Lunetta C, Ferraro OE, Falzone Y, Leocani L, Fazio R, Comola M, Comi G; CANALS Study Group. Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-con trolled, phase 2 trial. Lancet Neurol. 2019 Feb;18(2):155-164. doi: 10.1016/S1474-4422(18)30406-X. Epub 2018 Dec 13. PMID: 30554828.
Tarlarini C, Greco LC, Lizio A, Gerardi F, Sansone VA, Lunetta C. Taste changes in amyotrophic lateral sclerosis and effects on quality of life. Neurol Sci. 2019 Feb;40(2):399-404. doi: 10.1007/s10072-018-3672-z. Epub 2018 Dec 4. PMID: 30515604.
Sansone VA, Albamonte E, Salmin F, Casiraghi J, Pirola A, Bettinelli M, Rao F, Mancini L, Tovaglieri N, Fedeli F, Stoia P, Heinen M, Cozzi V, Car raro E, Lunetta C, Di Bari A, Mercuri E; Italian EAP working group. Intrathecal nusinersen treatment for SMA in a dedicated neuromuscular clinic: an example of multidisciplinary and integrated care. Neurol Sci. 2019 Feb;40(2):327-332. doi: 10.1007/s10072-018-3622-9. Epub 2018 Nov 15. PMID: 30430317.
Salvaggio G, Calamia M, Purpura P, Bartolotta TV, Picone D, Dispensa N, Lunetta C, Bruno A, Raso L, Salvaggio L, Lo Re G, Galia M, Simonato A, Midiri M, Lagalla R. Role of apparent diffusion coefficient values in prostate diseases characterization on diffusion-weighted magnetic reso nance imaging. Minerva Urol Nefrol. 2019 Apr;71(2):154-160. doi: 10.23736/S0393-2249.18.03065-5. Epub 2018 Nov 7. PMID: 30421590.
Lunetta C, Lizio A, Tremolizzo L, Ruscica M, Macchi C, Riva N, Weydt P, Corradi E, Magni P, Sansone V. Serum irisin is upregulated in patients affected by amyotrophic lateral sclerosis and correlates with functional and metabolic status. J Neurol. 2018 Dec;265(12):3001-3008. doi: 10.1007/s00415-018-9093-3. Epub 2018 Oct 22. PMID: 30350169.
Stoccoro A, Mosca L, Carnicelli V, Cavallari U, Lunetta C, Marocchi A, Migliore L, Coppedè F. Mitochondrial DNA copy number and D-loop region methylation in carriers of amyotrophic lateral sclerosis gene mutations. Epigenomics. 2018 Nov;10(11):1431-1443. doi: 10.2217/epi 2018-0072. Epub 2018 Aug 8. PMID: 30088417.
D'Ovidio F, Rooney JPK, Visser AE, Manera U, Beghi E, Logroscino G, Vermeulen RCH, Veldink JH, van den Berg LH, Hardiman O, Chiò A; Euro MOTOR consortium. Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study. J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):11-19. doi: 10.1136/jnnp-2018-318559. Epub 2018 Aug 3. PMID: 30076269.
Mandrioli J, D'Amico R, Zucchi E, Gessani A, Fini N, Fasano A, Caponnetto C, Chiò A, Dalla Bella E, Lunetta C, Mazzini L, Marinou K, Sorarù G, de Biasi S, Lo Tartaro D, Pinti M, Cossarizza A; RAP-ALS investigators group. Rapamycin treatment for amyotrophic lateral sclerosis: Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP-ALS trial). Medicine (Baltimore). 2018 Jun;97(24):e11119. doi: 10.1097/MD.0000000000011119. PMID: 29901635; PMCID: PMC6024184.
De Mattia E, Falcier E, Lizio A, Lunetta C, Sansone VA, Barbarito N, Garabelli B, Iatomasi M, Roma E, Rao F, Carlucci A. Passive Versus Active Circuit During Invasive Mechanical Ventilation in Subjects With Amyotrophic Lateral Sclerosis. Respir Care. 2018 Sep;63(9):1132-1138. doi: 10.4187/respcare.05866. Epub 2018 May 15. PMID: 29765003.
Visser AE, Rooney JPK, D'Ovidio F, Westeneng HJ, Vermeulen RCH, Beghi E, Chiò A, Logroscino G, Hardiman O, Veldink JH, van den Berg LH; Euro-MOTOR consortium. Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):797-803. doi: 10.1136/jnnp-2017-317724. Epub 2018 Apr 23. PMID: 29685899.
Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Shankaracharya, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A; ITALSGEN Consortium; Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, La Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D'Alfonso S, Corrado L, Capasso M, Ferrucci L; Genomic Translation for ALS Care (GTAC) Consortium; Moreno CAM, Kamalakaran S, Goldstein DB; ALS Sequencing Consortium; Gitler AD, Harris T, Myers RM; NYGC ALS Consortium; Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC; Answer ALS Foundation; Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, Van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E; Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium; Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J; SLAGEN Consortium; Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorarù G, Cereda C; French ALS Consortium; Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, Ten Asbroek ALMA, Muñoz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, Le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, Van Den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, Van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, Van Es MA, Weber M, Boylan KB, Van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-Pérez J, García-Redondo A, Al-Chalabi A; Project MinE ALS Sequencing Consortium; Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, Van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, Van Deerlin VM, Brown RH Jr, van den
Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chiò A, Shaw CE, Traynor BJ, Landers JE. Genome-wide Analyses Iden tify KIF5A as a Novel ALS Gene. Neuron. 2018 Mar 21;97(6):1268-1283.e6. doi: 10.1016/j.neuron.2018.02.027. PMID: 29566793; PMCID: PMC5867896.
Mandrioli J, Ferri L, Fasano A, Zucchi E, Fini N, Moglia C, Lunetta C, Marinou K, Ticozzi N, Drago Ferrante G, Scialo C, Sorarù G, Trojsi F, Conte A, Falzone YM, Tortelli R, Russo M, Sansone VA, Mora G, Silani V, Volanti P, Caponnetto C, Querin G, Monsurrò MR, Sabatelli M, Chiò A, Riva N, Logroscino G, Messina S, Calvo A. Cardiovascular diseases may play a negative role in the prognosis of amyotrophic lateral sclerosis. Eur J Neurol. 2018 Jun;25(6):861-868. doi: 10.1111/ene.13620. Epub 2018 Apr 15. PMID: 29512869.
Lattante S, Pomponi MG, Conte A, Marangi G, Bisogni G, Patanella AK, Meleo E, Lunetta C, Riva N, Mosca L, Carrera P, Bee M, Zollino M, Saba telli M. ATXN1 intermediate-length polyglutamine expansions are associated with amyotrophic lateral sclerosis. Neurobiol Aging. 2018 Apr;64:157.e1-157.e5. doi: 10.1016/j.neurobiolaging.2017.11.011. Epub 2017 Nov 28. PMID: 29274668.
Vitacca M, Montini A, Lunetta C, Banfi P, Bertella E, De Mattia E, Lizio A, Volpato E, Lax A, Morini R, Paneroni M; ALS RESPILOM Study Group. Impact of an early respiratory care programme with non-invasive ventilation adaptation in patients with amyotrophic lateral sclerosis. Eur J Neurol. 2018 Mar;25(3):556-e33. doi: 10.1111/ene.13547. Epub 2018 Jan 29. PMID: 29266547.
Crespi C, Dodich A, Cappa SF, Canessa N, Iannaccone S, Corbo M, Lunetta C, Falini A, Cerami C. Multimodal MRI quantification of the common neurostructural bases within the FTD-ALS continuum. Neurobiol Aging. 2018 Feb;62:95-104. doi: 10.1016/j.neurobiolaging.2017.09.019. Epub 2017 Sep 28. PMID: 29131982.
Pupillo E, Poloni M, Bianchi E, Giussani G, Logroscino G, Zoccolella S, Chiò A, Calvo A, Corbo M, Lunetta C, Marin B, Mitchell D, Hardiman O, Rooney J, Stevic Z, Bandettini di Poggio M, Filosto M, Cotelli MS, Perini M, Riva N, Tremolizzo L, Vitelli E, Damiani D, Beghi E; EURALS Consor tium†. Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):118-125. doi: 10.1080/21678421.2017.1386687. Epub 2017 Oct 24. PMID: 29063790.
van Eijk RPA, Jones AR, Sproviero W, Shatunov A, Shaw PJ, Leigh PN, Young CA, Shaw CE, Mora G, Mandrioli J, Borghero G, Volanti P, Diekstra FP, van Rheenen W, Verstraete E, Eijkemans MJC, Veldink JH, Chio A, Al-Chalabi A, van den Berg LH, van Es MA; For UKMND-LiCALS and LITALS Study Group. Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials. Neurology. 2017 Oct 31;89(18):1915-1922. doi: 10.1212/WNL.0000000000004606. Epub 2017 Oct 4. Erratum in: Neurology. 2017 Nov 28;89(22):2303. PMID: 28978660; PMCID: PMC5664299.
Portaro S, Calabrò RS, Bramanti P, Silvestri G, Torrisi M, Conti-Nibali V, Caliri S, Lunetta C, Alagna B, Naro A, Bramanti A. Telemedicine for Facio- Scapulo-Humeral Muscular Dystrophy: A multidisciplinary approach to improve quality of life and reduce hospitalization rate? Disabil Health J. 2018 Apr;11(2):306-309. doi: 10.1016/j.dhjo.2017.09.003. Epub 2017 Sep 21. PMID:
28967584.
Coppedè F, Stoccoro A, Mosca L, Gallo R, Tarlarini C, Lunetta C, Marocchi A, Migliore L, Penco S. Increase in DNA methylation in patients with amyotrophic lateral sclerosis carriers of not fully penetrant SOD1 mutations. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):93-101. doi: 10.1080/21678421.2017.1367401. Epub 2017 Sep 1. PMID: 28859526.
Spoladore D, Colombo V, Campanella V, Lunetta C, Mondellini M, Mahroo A, Cerri F, Sacco M. A Knowledge-based Decision Support System for recommending safe recipes to individuals with dysphagia. Comput Biol Med. 2024 Feb 19;171:108193. doi: 10.1016/j.compbio med.2024.108193. Epub ahead of print. PMID: 38387382.
Moreno-Martinez L, Macías-Redondo S, Strunk M, Guillén-Antonini MI, Lunetta C, Tarlarini C, Penco S, Calvo AC, Osta R, Schoorlemmer J. New Insights into Endogenous Retrovirus-K Transcripts in Amyotrophic Lateral Sclerosis. Int J Mol Sci. 2024 Jan 26;25(3):1549. doi: 10.3390/ijms25031549. PMID: 38338823; PMCID: PMC10855536.
Stoccoro A, Smith AR, Mosca L, Marocchi A, Gerardi F, Lunetta C, Lunnon K, Migliore L, Coppedè F. Mitochondrial D-loop methylation levels inversely correlate with disease duration in amyotrophic lateral sclerosis. Epigenomics. 2024 Feb;16(4):203-214. doi: 10.2217/epi-2023- 0265. Epub 2024 Feb 5. PMID: 38312023.
Lombardo FL, Spila Alegiani S, Mayer F, Cipriani M, Lo Giudice M, Ludolph AC, McDermott CJ, Corcia P, Van Damme P, Van den Berg LH, Har diman O, Nicolini G, Vanacore N, Dickie B, Albanese A, Puopolo M; TUDCA-ALS Study Group. A randomized double-blind clinical trial on safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS): the statis tical analysis plan of TUDCA-ALS trial. Trials. 2023 Dec 5;24(1):792. doi: 10.1186/s13063-023-07638-w. PMID: 38053196.
Sattin D, Parma C, Lunetta C, Zulueta A, Lanzone J, Giani L, Vassallo M, Picozzi M, Parati EA. An Overview of the Body Schema and Body Im age: Theoretical Models, Methodological Settings and Pitfalls for Rehabilitation of Persons with Neurological Disorders. Brain Sci. 2023 Oct 4;13(10):1410. doi: 10.3390/brainsci13101410. PMID: 37891779; PMCID: PMC10605253.
Pattee GL, Genge A, Couratier P, Lunetta C, Sobue G, Aoki M, Yoshino H, Jackson CE, Wymer J, Salah A, Nelson S. Oral Edaravone - Introducing a Flexible Treatment Option for Amyotrophic Lateral Sclerosis. Expert Rev Neurother. 2023 Jul-Dec;23(10):859-866. doi: 10.1080/14737175.2023.2251687. Epub 2023 Sep 12. PMID: 37646130.
Mandrioli J, D'Amico R, Zucchi E, De Biasi S, Banchelli F, Martinelli I, Simonini C, Lo Tartaro D, Vicini R, Fini N, Gianferrari G, Pinti M, Lunetta C, Gerardi F, Tarlarini C, Mazzini L, De Marchi F, Scognamiglio A, Sorarù G, Fortuna A, Lauria G, Bella ED, Caponnetto C, Meo G, Chio A, Calvo A, Cossarizza A. Randomized, double-blind, placebo-controlled trial of rapamycin in amyotrophic lateral sclerosis. Nat Commun. 2023 Aug 17;14(1):4970. doi: 10.1038/s41467-023-40734-8. PMID: 37591957; PMCID: PMC10435464.
Fortunato F, Bianchi F, Ricci G, Torri F, Gualandi F, Neri M, Farnè M, Giannini F, Malandrini A, Volpi N, Lopergolo D, Silani V, Ticozzi N, Verde F, Pareyson D, Fenu S, Bonanno S, Nigro V, Peduto C, D'Ambrosio P, Zeuli R, Zanobio M, Picillo E, Servidei S, Primiano G, Sancricca C, Sciacco M, Brusa R, Filosto M, Cotti Piccinelli S, Pegoraro E, Mongini T, Solero L, Gadaleta G, Brusa C, Minetti C, Bruno C, Panicucci C, Sansone VA, Lu
netta C, Zanolini A, Toscano A, Pugliese A, Nicocia G, Bertini E, Catteruccia M, Diodato D, Atalaia A, Evangelista T, Siciliano G, Ferlini A. Digital health and Clinical Patient Management System (CPMS) platform utility for data sharing of neuromuscular patients: the Italian EURO-NMD experience. Orphanet J Rare Dis. 2023 Jul 21;18(1):196. doi: 10.1186/s13023-023-02776-5. PMID: 37480080; PMCID: PMC10360326.
Berger A, Locatelli M, Arcila-Londono X, Hayat G, Olney N, Wymer J, Gwathmey K, Lunetta C, Heiman-Patterson T, Ajroud-Driss S, Macklin EA, Bind MA, Goslin K, Stuchiner T, Brown L, Bazan T, Regan T, Adamo A, Ferment V, Schroeder C, Somers M, Manousakis G, Faulconer K, Sinani E, Mirochnick J, Yu H, Sherman AV, Walk D; Pooled Resource Open-Access ALS Clinical Trials Consortium. The natural history of ALS: Baseline characteristics from a multicenter clinical cohort. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Jul 17:1-9. doi: 10.1080/21678421.2023.2232812. Epub ahead of print. PMID: 37461167.
Shefner JM, Musaro A, Ngo ST, Lunetta C, Steyn FJ, Robitaille R, De Carvalho M, Rutkove S, Ludolph AC, Dupuis L. Skeletal muscle in amyo trophic lateral sclerosis. Brain. 2023 Jun 16:awad202. doi: 10.1093/brain/awad202. Epub ahead of print. PMID: 37327376.
Aiello EN, Solca F, Greco LC, Torre S, Carelli L, Morelli C, Doretti A, Colombo E, Messina S, Pain D, Radici A, Lizio A, Casiraghi J, Cerri F, Woolley S, Murphy J, Tremolizzo L, Appollonio I, Verde F, Sansone VA, Lunetta C, Silani V, Ticozzi N, Poletti B. Equating norms between the ALS Cogni tive Behavioral Screen (ALS-CBS™) and the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) in non-demented ALS patients. J Neurol. 2023 Aug;270(8):4090-4095. doi: 10.1007/s00415-023-11749-4. Epub 2023 May 5. PMID: 37147520.
Canosa A, Calvo A, Mora G, Moglia C, Brunetti M, Barberis M, Borghero G, Caponnetto C, Trojsi F, Spataro R, Volanti P, Simone IL, Salvi F, Lo gullo FO, Riva N, Tremolizzo L, Giannini F, Mandrioli J, Tanel R, Murru MR, Mandich P, Conforti FL, Zollino M, Sabatelli M, Tarlarini C, Lunetta C, Mazzini L, D'Alfonso S, Guy N, Meininger V, Clavelou P, Camu W, Chiò A, On Behalf Of Italsgen Consortium. The HFE p.H63D (p.His63Asp) Polymorphism Is a Modifier of ALS Outcome in Italian and French Patients with SOD1 Mutations. Biomedicines. 2023 Feb 24;11(3):704. doi: 10.3390/biomedicines11030704. PMID: 36979682; PMCID: PMC10044845.
Corcia P, Lunetta C, Vourc'h P, Pradat PF, Blasco H. Time for optimism in ALS. Eur J Neurol. 2023 Feb 11. doi: 10.1111/ene.15738. Epub ahead of print. PMID: 36773012.
Aiello EN, Solca F, Greco LC, La Tona A, Torre S, Carelli L, Morelli C, Doretti A, Colombo E, Messina S, Pain D, Radici A, Lizio A, Casiraghi J, Cerri F, Brugnera A, Compare A, Woolley S, Murphy J, Tremolizzo L, Appollonio I, Verde F, Sansone VA, Lunetta C, Silani V, Ticozzi N, Poletti B. Standardization of the Italian ALS-CBS™ Caregiver Behavioral Questionnaire. Front Psychol. 2023 Jan 20;13:1107001. doi: 10.3389/fpsyg.2022.1107001. PMID: 36743632; PMCID: PMC9896625.
Aiello EN, Greco LC, La Tona A, Solca F, Torre S, Carelli L, Pain D, Radici A, Lizio A, Casiraghi J, Cerri F, Brugnera A, Compare A, Woolley S, Mur phy J, Tremolizzo L, Appollonio I, Verde F, Silani V, Ticozzi N, Lunetta C, Sansone VA, Poletti B. Clinimetrics of the cognitive section of the Italian ALS Cognitive Behavioral Screen (ALS-CBS™). Neurol Sci. 2022 Dec 22. doi: 10.1007/s10072-022-06569-9. Epub ahead of print. PMID: 36547779.
Genge A, Pattee GL, Sobue G, Aoki M, Yoshino H, Couratier P, Lunetta C, Petri S, Selness D, Bidani S, Hirai M, Sakata T, Salah A, Apple S, Wamil A, Kalin A, Jackson CE. Oral edaravone demonstrated a favorable safety profile in patients with amyotrophic lateral sclerosis after 48 weeks of treatment. Muscle Nerve. 2023 Feb;67(2):124-129. doi: 10.1002/mus.27768. Epub 2022 Dec 28. PMID: 36504406.
Albanese A, Ludolph AC, McDermott CJ, Corcia P, Van Damme P, Van den Berg LH, Hardiman O, Rinaldi G, Vanacore N, Dickie B; TUDCA-ALS Study Group. Tauroursodeoxycholic acid in patients with amyotrophic lateral sclerosis: The TUDCA-ALS trial protocol. Front Neurol. 2022 Sep 27;13:1009113. doi: 10.3389/fneur.2022.1009113. PMID: 36237618; PMCID: PMC9552801.
Beghi E, Pupillo E, Bianchi E, Bonetto V, Luotti S, Pasetto L, Bendotti C, Tortarolo M, Sironi F, Camporeale L, Sherman AV, Paganoni S, Scogna miglio A, De Marchi F, Bongioanni P, Del Carratore R, Caponnetto C, Diamanti L, Martinelli D, Calvo A, Filosto M, Padovani A, Piccinelli SC, Ricci C, Dalla Giacoma S, De Angelis N, Inghilleri M, Spataro R, La Bella V, Logroscino G, Lunetta C, Tarlarini C, Mandrioli J, Martinelli I, Simo nini C, Zucchi E, Monsurrò MR, Ricciardi D, Trojsi F, Riva N, Filippi M, Simone IL, Sorarù G, Spera C, Florio L, Messina S, Russo M, Siciliano G, Conte A, Saddi MV, Carboni N, Mazzini L; RNS60-ALS Study Group. Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial. Eur J Neurol. 2023 Jan;30(1):69-86. doi: 10.1111/ene.15573. Epub 2022 Oct 7. PMID: 36148821.
Campisi L, Chizari S, Ho JSY, Gromova A, Arnold FJ, Mosca L, Mei X, Fstkchyan Y, Torre D, Beharry C, Garcia-Forn M, Jiménez-Alcázar M, Korobeynikov VA, Prazich J, Fayad ZA, Seldin MM, De Rubeis S, Bennett CL, Ostrow LW, Lunetta C, Squatrito M, Byun M, Shneider NA, Jiang N, La Spada AR, Marazzi I. Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature. 2022 Jun;606(7916):945-952. doi: 10.1038/s41586-022-04844-5. Epub 2022 Jun 22. Erratum in: Nature. 2022 Aug;608(7924):E34. PMID: 35732742.
Lunetta C, Lizio A, Cabona C, Gerardi F, Sansone VA, Corbo M, Scialò C, Angelucci E, Gualandi F, Marenco P, Grillo G, Cairoli R, Cesana C, Sac cardi R, Melazzini MG, Mancardi G, Caponnetto C. A phase I/IIa clinical trial of autologous hematopoietic stem cell transplantation in amyo trophic lateral sclerosis. J Neurol. 2022 Oct;269(10):5337-5346. doi: 10.1007/s00415-022-11185-w. Epub 2022 May 21. PMID: 35596795.
Tavazzi E, Daberdaku S, Zandonà A, Vasta R, Nefussy B, Lunetta C, Mora G, Mandrioli J, Grisan E, Tarlarini C, Calvo A, Moglia C, Drory V, Got kine M, Chiò A, Di Camillo B; Piemonte, Valle d’Aosta Register for ALS (PARALS), for the Emilia Romagna Registry for ALS (ERRALS). Predict ing functional impairment trajectories in amyotrophic lateral sclerosis: a probabilistic, multifactorial model of disease progression. J Neurol. 2022 Jul;269(7):3858-3878. doi: 10.1007/s00415-022-11022-0. Epub 2022 Mar 10. PMID: 35266043; PMCID: PMC9217910.
Kliest T, Van Eijk RPA, Al-Chalabi A, Albanese A, Andersen PM, Amador MDM, BrÅthen G, Brunaud-Danel V, Brylev L, Camu W, De Carvalho M, Cereda C, Cetin H, Chaverri D, Chiò A, Corcia P, Couratier P, De Marchi F, Desnuelle C, Van Es MA, Esteban J, Filosto M, GarcÍa Redondo A, Grosskreutz J, Hanemann CO, HolmØy T, HØyer H, Ingre C, Koritnik B, Kuzma-Kozakiewicz M, Lambert T, Leigh PN, Lunetta C, Mandrioli J, Mcdermott CJ, Meyer T, Mora JS, Petri S, Povedano M, Reviers E, Riva N, Roes KCB, Rubio MÁ, Salachas F, Sarafov S, SorarÙ G, Stevic Z, Sven strup K, MØller AT, Turner MR, Van Damme P, Van Leeuwen LAG, Varona L, VÁzquez Costa JF, Weber M, Hardiman O, Van Den Berg LH. Clini cal trials in pediatric ALS: a TRICALS feasibility study. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Nov;23(7-8):481-488. doi: 10.1080/21678421.2021.2024856. Epub 2022 Feb 16. PMID: 35172656; PMCID: PMC9662181.
Riva N, Gentile F, Cerri F, Gallia F, Podini P, Dina G, Falzone YM, Fazio R, Lunetta C, Calvo A, Logroscino G, Lauria G, Corbo M, Iannaccone S, Chiò A, Lazzerini A, Nobile-Orazio E, Filippi M, Quattrini A. Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis. Brain. 2022 Mar 29;145(1):276-284. doi: 10.1093/brain/awab285. PMID: 35076694; PMCID: PMC8967102.
Pugliese R, Sala R, Regondi S, Beltrami B, Lunetta C. Emerging technologies for management of patients with amyotrophic lateral sclerosis: from telehealth to assistive robotics and neural interfaces. J Neurol. 2022 Jun;269(6):2910-2921. doi: 10.1007/s00415-022-10971-w. Epub 2022 Jan 21. PMID: 35059816; PMCID: PMC8776511.
Ami D, Duse A, Mereghetti P, Cozza F, Ambrosio F, Ponzini E, Grandori R, Lunetta C, Tavazzi S, Pezzoli F, Natalello A. Tear-Based Vibrational Spectroscopy Applied to Amyotrophic Lateral Sclerosis. Anal Chem. 2021 Dec 28;93(51):16995-17002. doi: 10.1021/acs.analchem.1c02546. Epub 2021 Dec 14. PMID: 34905686; PMCID: PMC8717331.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra HJ, Bakker OB, Deelen P, Shireby G, Hannon E, Moisse M, Baird D, Restuadi R, Dolzhenko E, Dekker AM, Gawor K, Westeneng HJ, Tazelaar GHP, van Eijk KR, Kooyman M, Byrne RP, Doherty M, Heverin M, Al Khleifat A, Iacoangeli A, Shatunov A, Ticozzi N, Cooper-Knock J, Smith BN, Gromicho M, Chandran S, Pal S, Morri son KE, Shaw PJ, Hardy J, Orrell RW, Sendtner M, Meyer T, Başak N, van der Kooi AJ, Ratti A, Fogh I, Gellera C, Lauria G, Corti S, Cereda C, Sproviero D, D'Alfonso S, Sorarù G, Siciliano G, Filosto M, Padovani A, Chiò A, Calvo A, Moglia C, Brunetti M, Canosa A, Grassano M, Beghi E, Pupillo E, Logroscino G, Nefussy B, Osmanovic A, Nordin A, Lerner Y, Zabari M, Gotkine M, Baloh RH, Bell S, Vourc'h P, Corcia P, Couratier P, Millecamps S, Meininger V, Salachas F, Mora Pardina JS, Assialioui A, Rojas-García R, Dion PA, Ross JP, Ludolph AC, Weishaupt JH, Brenner D, Freischmidt A, Bensimon G, Brice A, Durr A, Payan CAM, Saker-Delye S, Wood NW, Topp S, Rademakers R, Tittmann L, Lieb W, Franke A, Ripke S, Braun A, Kraft J, Whiteman DC, Olsen CM, Uitterlinden AG, Hofman A, Rietschel M, Cichon S, Nöthen MM, Amouyel P; SLALOM Con sortium; PARALS Consortium; SLAGEN Consortium; SLAP Consortium; Traynor BJ, Singleton AB, Mitne Neto M, Cauchi RJ, Ophoff RA, Wiedau-Pazos M, Lomen-Hoerth C, van Deerlin VM, Grosskreutz J, Roediger A, Gaur N, Jörk A, Barthel T, Theele E, Ilse B, Stubendorff B, Witte OW, Steinbach R, Hübner CA, Graff C, Brylev L, Fominykh V, Demeshonok V, Ataulina A, Rogelj B, Koritnik B, Zidar J, Ravnik-Glavač M, Glavač D, Stević Z, Drory V, Povedano M, Blair IP, Kiernan MC, Benyamin B, Henderson RD, Furlong S, Mathers S, McCombe PA, Needham M, Ngo ST, Nicholson GA, Pamphlett R, Rowe DB, Steyn FJ, Williams KL, Mather KA, Sachdev PS, Henders AK, Wallace L, de Carvalho M, Pinto S, Petri S, Weber M, Rouleau GA, Silani V, Curtis CJ, Breen G, Glass JD, Brown RH Jr, Landers JE, Shaw CE, Andersen PM, Groen EJN, van Es MA, Paster kamp RJ, Fan D, Garton FC, McRae AF, Davey Smith G, Gaunt TR, Eberle MA, Mill J, McLaughlin RL, Hardiman O, Kenna KP, Wray NR, Tsai E, Runz H, Franke L, Al-Chalabi A, Van Damme P, van den Berg LH, Veldink JH. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet. 2021 Dec;53(12):1636-1648. doi: 10.1038/s41588-021-00973-1. Epub 2021 Dec 6. Erratum in: Nat Genet. 2022 Mar;54(3):361. PMID: 34873335; PMCID: PMC8648564.
Diamanti L, Borrelli P, Dubbioso R, Capasso M, Morelli C, Lunetta C, Petrucci A, Mora G, Volanti P, Inghilleri M, Tremolizzo L, Mandrioli J, Maz zini L, Vedovello M, Siciliano G, Filosto M, Matà S, Montomoli C; DYALS Study Group. Validation of the DYALS (dysphagia in amyotrophic lat eral sclerosis) questionnaire for the evaluation of dysphagia in ALS patients. Neurol Sci. 2022 May;43(5):3195-3200. doi:10.1007/s10072- 021-05775-1. Epub 2021 Dec 1. PMID: 34853898.
Carraro E, Casiraghi JL, Bobba B, Lizio A, Cardella C, Albamonte E, Lunetta C, Pozzi S, Sansone VA. Wheelchair hockey improves quality of life in people with neuromuscular disease. PM R. 2022 Dec;14(12):1446-1453. doi: 10.1002/pmrj.12736. Epub 2022 Jan 11. PMID: 34773450. Corcia P, Lunetta C, Couratier P, Vourc'h P, Gromicho M, Desnuelle C, Soriani MH, Pinto S, de Carvalho M. Reply to the letter from Gazulla et al. Eur J Neurol. 2022 Jan;29(1):e3-e4. doi: 10.1111/ene.15134. Epub 2021 Oct 18. PMID: 34624147.
Ginocchio D, Ninfa A, Pizzorni N, Lunetta C, Sansone VA, Schindler A. Cross-Cultural Adaptation and Validation of the Italian Version of the Dysphagia Handicap Index (I-DHI). Dysphagia. 2022 Oct;37(5):1120-1136. doi: 10.1007/s00455-021-10369-2. Epub 2021 Sep 28. PMID: 34581857; PMCID: PMC9463219.
Poletti B, Solca F, Carelli L, Diena A, Colombo E, Torre S, Maranzano A, Greco L, Cozza F, Lizio A, Ferrucci R, Girotti F, Verde F, Morelli C, Lu netta C, Silani V, Ticozzi N. Association of Clinically Evident Eye Movement Abnormalities With Motor and Cognitive Features in Patients With Motor Neuron Disorders. Neurology. 2021 Nov 2;97(18):e1835-e1846. doi: 10.1212/WNL.0000000000012774. Epub 2021 Sep 9. PMID: 34504031.
Johnson JO, Chia R, Miller DE, Li R, Kumaran R, Abramzon Y, Alahmady N, Renton AE, Topp SD, Gibbs JR, Cookson MR, Sabir MS, Dalgard CL, Troakes C, Jones AR, Shatunov A, Iacoangeli A, Al Khleifat A, Ticozzi N, Silani V, Gellera C, Blair IP, Dobson-Stone C, Kwok JB, Bonkowski ES, Palvadeau R, Tienari PJ, Morrison KE, Shaw PJ, Al-Chalabi A, Brown RH Jr, Calvo A, Mora G, Al-Saif H, Gotkine M, Leigh F, Chang IJ, Perlman SJ, Glass I, Scott AI, Shaw CE, Basak AN, Landers JE, Chiò A, Crawford TO, Smith BN, Traynor BJ; FALS Sequencing Consortium; American Genome Center; International ALS Genomics Consortium; and ITALSGEN Consortium; Smith BN, Ticozzi N, Fallini C, Gkazi AS, Topp SD, Scotter EL, Kenna KP, Keagle P, Tiloca C, Vance C, Troakes C, Colombrita C, King A, Pensato V, Castellotti B, Baas F, Ten Asbroek ALMA, McKenna Yasek D, McLaughlin RL, Polak M, Asress S, Esteban-Pérez J, Stevic Z, D'Alfonso S, Mazzini L, Comi GP, Del Bo R, Ceroni M, Gagliardi S, Querin
G, Bertolin C, van Rheenen W, Rademakers R, van Blitterswijk M, Lauria G, Duga S, Corti S, Cereda C, Corrado L, Sorarù G, Williams KL, Nichol son GA, Blair IP, Leblond-Manry C, Rouleau GA, Hardiman O, Morrison KE, Veldink JH, van den Berg LH, Al-Chalabi A, Pall H, Shaw PJ, Turner MR, Talbot K, Taroni F, García-Redondo A, Wu Z, Glass JD, Gellera C, Ratti A, Brown RH Jr, Silani V, Shaw CE, Landers JE, Dalgard CL, Adeleye A, Soltis AR, Alba C, Viollet C, Bacikova D, Hupalo DN, Sukumar G, Pollard HB, Wilkerson MD, Martinez EM, Abramzon Y, Ahmed S, Arepalli S,
Baloh RH, Bowser R, Brady CB, Brice A, Broach J, Campbell RH, Camu W, Chia R, Cooper-Knock J, Ding J, Drepper C, Drory VE, Dunckley TL, Eicher JD, England BK, Faghri F, Feldman E, Floeter MK, Fratta P, Geiger JT, Gerhard G, Gibbs JR, Gibson SB, Glass JD, Hardy J, Harms MB, Heiman-Patterson TD, Hernandez DG, Jansson L, Kirby J, Kowall NW, Laaksovirta H, Landeck N, Landi F, Le Ber I, Lumbroso S, MacGowan DJL, Maragakis NJ, Mora G, Mouzat K, Murphy NA, Myllykangas L, Nalls MA, Orrell RW, Ostrow LW, Pamphlett R, Pickering-Brown S, Pioro EP, Pletnikova O, Pliner HA, Pulst SM, Ravits JM, Renton AE, Rivera A, Robberecht W, Rogaeva E, Rollinson S, Rothstein JD, Scholz SW, Sendtner M, Shaw PJ, Sidle KC, Simmons Z, Singleton AB, Smith N, Stone DJ, Tienari PJ, Troncoso JC, Valori M, Van Damme P, Van Deerlin VM, Van Den Bosch L, Zinman L, Landers JE, Chiò A, Traynor BJ, Angelocola SM, Ausiello FP, Barberis M, Bartolomei I, Battistini S, Bersano E, Bisogni G, Borghero G, Brunetti M, Cabona C, Calvo A, Canale F, Canosa A, Cantisani TA, Capasso M, Caponnetto C, Cardinali P, Carrera P, Casale F, Chiò A, Colletti T, Conforti FL, Conte A, Conti E, Corbo M, Cuccu S, Dalla Bella E, D'Errico E, DeMarco G, Dubbioso R, Ferrarese C, Ferraro PM, Filippi M, Fini N, Floris G, Fuda G, Gallone S, Gianferrari G, Giannini F, Grassano M, Greco L, Iazzolino B, Introna A, La Bella V, Lattante S, Lauria G, Li guori R, Logroscino G, Logullo FO, Lunetta C, Mandich P, Mandrioli J, Manera U, Manganelli F, Marangi G, Marinou K, Marrosu MG, Martinelli I, Messina S, Moglia C, Mora G, Mosca L, Murru MR, Origone P, Passaniti C, Petrelli C, Petrucci A, Pozzi S, Pugliatti M, Quattrini A, Ricci C, Riolo G, Riva N, Russo M, Sabatelli M, Salamone P, Salivetto M, Salvi F, Santarelli M, Sbaiz L, Sideri R, Simone I, Simonini C, Spataro R, Tanel R, Tedeschi G, Ticca A, Torriello A, Tranquilli S, Tremolizzo L, Trojsi F, Vasta R, Vacchiano V, Vita G, Volanti P, Zollino M, Zucchi E. Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis. JAMA Neurol. 2021 Oct 1;78(10):1236-1248. doi: 10.1001/jamaneu rol.2021.2598. PMID: 34459874; PMCID: PMC8406220.
Greco LC, Lizio A, Casiraghi J, Sansone VA, Tremolizzo L, Riva N, Solca F, Torre S, Ticozzi N, Filippi M, Silani V, Poletti B, Lunetta C. A prelimi nary comparison between ECAS and ALS-CBS in classifying cognitive-behavioural phenotypes in a cohort of non-demented amyotrophic lateral sclerosis patients. J Neurol. 2022 Apr;269(4):1899-1904. doi: 10.1007/s00415-021-10753-w. Epub 2021 Aug 19. PMID: 34410493.
Pasetto L, Callegaro S, Corbelli A, Fiordaliso F, Ferrara D, Brunelli L, Sestito G, Pastorelli R, Bianchi E, Cretich M, Chiari M, Potrich C, Moglia C, Corbo M, Sorarù G, Lunetta C, Calvo A, Chiò A, Mora G, Pennuto M, Quattrone A, Rinaldi F, D'Agostino VG, Basso M, Bonetto V. Decoding di stinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis. Mol Neurodegener. 2021 Aug 10;16(1):52. doi: 10.1186/s13024-021-00470-3. PMID: 34376243; PMCID: PMC8353748.
Cattaneo M, Jesus P, Lizio A, Fayemendy P, Guanziroli N, Corradi E, Sansone V, Leocani L, Filippi M, Riva N, Corcia P, Couratier P, Lunetta C. The hypometabolic state: a good predictor of a better prognosis in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2022 Jan;93(1):41-47. doi: 10.1136/jnnp-2021-326184. Epub 2021 Aug 5. PMID: 34353859.
Corcia P, Lunetta C, Couratier P, Vourc'h P, Gromicho M, Desnuelle C, Soriani MH, Pinto S, de Carvalho M. Familial clustering of primary lat eral sclerosis and amyotrophic lateral sclerosis: Supplementary evidence for a continuum. Eur J Neurol. 2021 Aug;28(8):2780-2783. doi: 10.1111/ene.14960. Epub 2021 Jun 23. PMID: 34110677.
Barp A, Lizio A, Gerardi F, Tarlarini C, Mauro L, Sansone VA, Lunetta C. Neurophysiological indices in amyotrophic lateral sclerosis correlate with functional outcome measures, staging and disease progression. Clin Neurophysiol. 2021 Jul;132(7):1564-1571. doi: 10.1016/j.clinph.2021.02.394. Epub 2021 Apr 7. PMID: 34023632.
Dalla Bella E, Bersano E, Antonini G, Borghero G, Capasso M, Caponnetto C, Chiò A, Corbo M, Filosto M, Giannini F, Spataro R, Lunetta C, Man drioli J, Messina S, Monsurrò MR, Mora G, Riva N, Rizzi R, Siciliano G, Silani V, Simone I, Sorarù G, Tugnoli V, Verriello L, Volanti P, Furlan R, Nolan JM, Abgueguen E, Tramacere I, Lauria G. The unfolded protein response in amyotrophic later sclerosis: results of a phase 2 trial. Brain. 2021 Oct 22;144(9):2635-2647. doi: 10.1093/brain/awab167. PMID: 33905493; PMCID: PMC8557337.
Moreno-García L, Miana-Mena FJ, Moreno-Martínez L, de la Torre M, Lunetta C, Tarlarini C, Zaragoza P, Calvo AC, Osta R. Inflammasome in ALS Skeletal Muscle: <i>NLRP3</i> as a Potential Biomarker. Int J Mol Sci. 2021 Mar 3;22(5):2523. doi: 10.3390/ijms22052523. PMID: 33802349; PMCID: PMC7959138.
Storti B, Diamanti S, Tremolizzo L, Riva N, Lunetta C, Filippi M, Ferrarese C, Appollonio I. ALS Mimics due to Affection of the Cervical Spine: From Common Compressive Myelopathy to Rare CSF Epidural Collection. Case Rep Neurol. 2021 Mar 4;13(1):145-156. doi: 10.1159/000512810. PMID: 33790773; PMCID: PMC7989791.
Barp A, Velardo D, Ciscato P, Sansone VA, Lunetta C. Anti-HMGCR myopathy misdiagnosed as motor neuron disease and complicated with COVID-19 infection. Neurol Sci. 2021 May;42(5):1679-1682. doi: 10.1007/s10072-021-05146-w. Epub 2021 Mar 1. PMID: 33646438; PMCID: PMC7917165.
Lanteri P, Meola I, Canosa A, De Marco G, Lomartire A, Rinaudo MT, Albamonte E, Sansone VA, Lunetta C, Manera U, Vasta R, Moglia C, Calvo A, Origone P, Chiò A, Mandich P. The heterozygous deletion c.1509_1510delAG in exon 14 of FUS causes an aggressive childhood-onset ALS with cognitive impairment. Neurobiol Aging. 2021 Jul;103:130.e1-130.e7. doi: 10.1016/j.neurobiolaging.2021.01.029. Epub 2021 Feb 3. PMID: 33637330.
Cozza F, Lizio A, Greco LC, Bona S, Donvito G, Carraro E, Tavazzi S, Ticozzi N, Poletti B, Sansone VA, Lunetta C. Ocular Involvement Occurs Frequently at All Stages of Amyotrophic Lateral Sclerosis: Preliminary Experience in a Large Italian Cohort. J Clin Neurol. 2021 Jan;17(1):96- 105. doi: 10.3988/jcn.2021.17.1.96. PMID: 33480204; PMCID: PMC7840315.
Conti E, Sala G, Diamanti S, Casati M, Lunetta C, Gerardi F, Tarlarini C, Mosca L, Riva N, Falzone Y, Filippi M, Appollonio I, Ferrarese C, Tremo lizzo L. Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis. Sci Rep. 2021 Jan 21;11(1):1978. doi: 10.1038/s41598-021-81599-5. PMID: 33479441; PMCID: PMC7820419.
Barp A, Ada Sansone V, Lunetta C. Challenges in diagnosis of motor neuron disease: A case series of ALS mimic syndromes. Rev Neurol (Paris). 2021 Jun;177(6):699-706. doi: 10.1016/j.neurol.2020.08.010. Epub 2020 Dec 31. PMID: 33390263.
Crespi C, Santi GC, Dodich A, Lupo F, Greco LC, Piccoli T, Lunetta C, Cerami C. Unraveling Moral Reasoning in Amyotrophic Lateral Sclerosis: How Emotional Detachment Modifies Moral Judgment. Front Psychol. 2020 Aug 21;11:2083. doi: 10.3389/fpsyg.2020.02083. PMID: 32973626; PMCID: PMC7471658.
Russo M, Lunetta C, Zuccarino R, Vita GL, Sframeli M, Lizio A, La Foresta S, Faraone C, Sansone VA, Vita G, Messina S. The 6-min walk test as a new outcome measure in Amyotrophic lateral sclerosis. Sci Rep. 2020 Sep 23;10(1):15580. doi: 10.1038/s41598-020-72578-3. PMID: 32968168; PMCID: PMC7511965.
Stoccoro A, Smith AR, Mosca L, Marocchi A, Gerardi F, Lunetta C, Cereda C, Gagliardi S, Lunnon K, Migliore L, Coppedè F. Reduced mitochon drial D-loop methylation levels in sporadic amyotrophic lateral sclerosis. Clin Epigenetics. 2020 Sep 11;12(1):137. doi: 10.1186/s13148-020- 00933-2. PMID: 32917270; PMCID: PMC7488473.
Tondo G, Iaccarino L, Cerami C, Vanoli GE, Presotto L, Masiello V, Coliva A, Salvi F, Bartolomei I, Mosca L, Lunetta C, Perani D. <sup>11</sup> C-PK11195 PET-based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis. Ann Clin Transl Neurol. 2020 Sep;7(9):1513-1523. doi: 10.1002/acn3.51112. Epub 2020 Aug 6. PMID: 32762033; PMCID: PMC7480909.
Barp A, Carraro E, Albamonte E, Salmin F, Lunetta C, Comi GP, Messina C, Albano D, Chianca V, Sconfienza LM, Mercuri EM, Sansone VA. Mus cle MRI in two SMA patients on nusinersen treatment: A two years follow-up. J Neurol Sci. 2020 Oct 15;417:117067. doi: 10.1016/j.jns.2020.117067. Epub 2020 Jul 29. PMID: 32745721; PMCID: PMC7388822.
Russo M, Bonanno C, Profazio C, La Foresta S, Faraone C, Lizio A, Vita GL, Sframeli M, Aricò I, Ruggeri P, Toscano A, Vita G, Lunetta C, Messina S. Which are the factors influencing NIV adaptation and tolerance in ALS patients? Neurol Sci. 2021 Mar;42(3):1023-1029. doi: 10.1007/s10072-020-04624-x. Epub 2020 Jul 24. PMID: 32710206.
Schito P, Ceccardi G, Calvo A, Falzone YM, Moglia C, Lunetta C, Marinou K, Ticozzi N, Scialo C, Sorarù G, Trojsi F, Conte A, Tortelli R, Russo M, Zucchi E, Pozzi L, Domi T, Carrera P, Agosta F, Quattrini A, Fazio R, Chiò A, Sansone VA, Mora G, Silani V, Volanti P, Caponnetto C, Querin G, Tedeschi G, Sabatelli M, Logroscino G, Messina S, Mandrioli J, Riva N, Filippi M. Clinical features and outcomes of the flail arm and flail leg and pure lower motor neuron MND variants: a multicentre Italian study. J Neurol Neurosurg Psychiatry. 2020 Sep;91(9):1001-1003. doi: 10.1136/jnnp-2020-323542. Epub 2020 Jul 10. PMID: 32651246.
Lunetta C, Lizio A, Gerardi F, Tarlarini C, Filippi M, Riva N, Tremolizzo L, Diamanti S, Dellanoce CC, Mosca L, Sansone VA, Campolo J. Urinary neopterin, a new marker of the neuroinflammatory status in amyotrophic lateral sclerosis. J Neurol. 2020 Dec;267(12):3609-3616. doi: 10.1007/s00415-020-10047-7. Epub 2020 Jul 8. PMID: 32638112.
Bendotti C, Bonetto V, Pupillo E, Logroscino G, Al-Chalabi A, Lunetta C, Riva N, Mora G, Lauria G, Weishaupt JH, Agosta F, Malaspina A, Basso M, Greensmith L, Van Den Bosch L, Ratti A, Corbo M, Hardiman O, Chiò A, Silani V, Beghi E. Focus on the heterogeneity of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Nov;21(7-8):485-495. doi: 10.1080/21678421.2020.1779298. Epub 2020 Jun 25. PMID: 32583689.
Lunetta C, Moglia C, Lizio A, Caponnetto C, Dubbioso R, Giannini F, Matà S, Mazzini L, Sabatelli M, Siciliano G, Simone IL, Sorarù G, Toriello A, Trojsi F, Vedovello M, D'Ovidio F, Filippi M, Calvo A; and EDARAVALS Study Group. The Italian multicenter experience with edaravone in amyotrophic lateral sclerosis. J Neurol. 2020 Nov;267(11):3258-3267. doi: 10.1007/s00415-020-09993-z. Epub 2020 Jun 17. PMID: 32556567.
Barp A, Gerardi F, Lizio A, Sansone VA, Lunetta C. Emerging Drugs for the Treatment of Amyotrophic Lateral Sclerosis: A Focus on Recent Phase 2 Trials. Expert Opin Emerg Drugs. 2020 Jun;25(2):145-164. doi:
10.1080/14728214.2020.1769067. Epub 2020 May 27. PMID: 32456491.
Poletti B, Carelli L, Lunetta C, Ticozzi N, Silani V. Advance care planning and mental capacity in ALS: a current challenge for an unsolved mat ter. Neurol Sci. 2020 Oct;41(10):2997-2998. doi: 10.1007/s10072-020-04462-x. Epub 2020 May 20. PMID: 32435995.
Schijven D, Stevelink R, McCormack M, van Rheenen W, Luykx JJ, Koeleman BPC, Veldink JH; Project MinE ALS GWAS Consortium; Interna tional League Against Epilepsy Consortium on Complex Epilepsies. Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy. Neurobiol Aging. 2020 Aug;92:153.e1-153.e5. doi: 10.1016/j.neurobiolaging.2020.04.011. Epub 2020 Apr 18. PMID: 32409253; PMCID: PMC7818383.
Scarlino S, Domi T, Pozzi L, Romano A, Pipitone GB, Falzone YM, Mosca L, Penco S, Lunetta C, Sansone V, Tremolizzo L, Fazio R, Agosta F, Filippi M, Carrera P, Riva N, Quattrini A. Burden of Rare Variants in ALS and Axonal Hereditary Neuropathy Genes Influence Survival in ALS: Insights from a Next Generation Sequencing Study of an Italian ALS Cohort. Int J Mol Sci. 2020 May 8;21(9):3346. doi: 10.3390/ijms21093346. PMID: 32397312; PMCID: PMC7246633.
Loffreda A, Nizzardo M, Arosio A, Ruepp MD, Calogero RA, Volinia S, Galasso M, Bendotti C, Ferrarese C, Lunetta C, Rizzuti M, Ronchi AE, Mühlemann O, Tremolizzo L, Corti S, Barabino SML. miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis. Prog Neurobiol. 2020 Jul;190:101803. doi: 10.1016/j.pneurobio.2020.101803. Epub 2020 Apr 24. PMID: 32335272.
De Mattia E, Lizio A, Falcier E, Sannicolò G, Gualandris M, Rossi G, Zanolini A, Pozzi S, Messina S, Sframeli M, Lunetta C, Rao F, Sansone VA. Screening for early symptoms of respiratory involvement in myotonic dystrophy type 1 using the Respicheck questionnaire. Neuromuscul Disord. 2020 Apr;30(4):301-309. doi: 10.1016/j.nmd.2020.02.014. Epub 2020 Feb 29. PMID: 32305258.
Salamone P, Fuda G, Casale F, Marrali G, Lunetta C, Caponnetto C, Mazzini L, La Bella V, Mandrioli J, Simone IL, Moglia C, Calvo A, Tarella C, Chio A; STEMALS-II Study Group. G-CSF (filgrastim) treatment for amyotrophic lateral sclerosis: protocol for a phase II randomised, double blind, placebo-controlled, parallel group, multicentre clinical study (STEMALS-II trial). BMJ Open. 2020 Mar 24;10(3):e034049. doi: 10.1136/bmjopen-2019-034049. PMID: 32209625; PMCID: PMC7202695.
Luotti S, Pasetto L, Porcu L, Torri V, Elezgarai SR, Pantalone S, Filareti M, Corbo M, Lunetta C, Mora G, Bonetto V. Diagnostic and prognostic values of PBMC proteins in amyotrophic lateral sclerosis. Neurobiol Dis. 2020 Jun;139:104815. doi: 10.1016/j.nbd.2020.104815. Epub 2020 Feb 20. PMID: 32087285.
De Schaepdryver M, Lunetta C, Tarlarini C, Mosca L, Chio A, Van Damme P, Poesen K. Neurofilament light chain and C reactive protein ex plored as predictors of survival in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2020 Apr;91(4):436-437. doi: 10.1136/jnnp 2019-322309. Epub 2020 Feb 6. PMID: 32029541.
Tremolizzo L, Lizio A, Santangelo G, Diamanti S, Lunetta C, Gerardi F, Messina S, La Foresta S, Riva N, Falzone Y, Filippi M, Woolley SC, San sone VA, Siciliano M, Ferrarese C, Appollonio I; ALS-CBS Italian Study Group. ALS Cognitive Behavioral Screen (ALS-CBS): normative values for the Italian population and clinical usability. Neurol Sci. 2020 Apr;41(4):835-841. doi: 10.1007/s10072-019-04154-1. Epub 2019 Dec 5. PMID: 31807998.
Bona S, Donvito G, Cozza F, Malberti I, Vaccari P, Lizio A, Greco L, Carraro E, Sansone VA, Lunetta C. The development of an augmented reality device for the autonomous management of the electric bed and the electric wheelchair for patients with amyotrophic lateral sclerosis: a pilot study. Disabil Rehabil Assist Technol. 2021 Jul;16(5):513-519. doi: 10.1080/17483107.2019.1683237. Epub 2019 Nov 5. PMID: 31686552.
Arosio A, Cristofani R, Pansarasa O, Crippa V, Riva C, Sirtori R, Rodriguez- Menendez V, Riva N, Gerardi F, Lunetta C, Cereda C, Poletti A, Fer rarese C, Tremolizzo L, Sala G. HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accu mulation. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Feb;21(1-2):51-62. doi: 10.1080/21678421.2019.1672749. Epub 2019 Oct 30. PMID: 31663379.
Pirola A, De Mattia E, Lizio A, Sannicolò G, Carraro E, Rao F, Sansone V, Lunetta C. The prognostic value of spirometric tests in Amyotrophic Lateral Sclerosis patients. Clin Neurol Neurosurg. 2019 Sep;184:105456. doi: 10.1016/j.clineuro.2019.105456. Epub 2019 Jul 29. PMID: 31382080.
Sala G, Arosio A, Conti E, Beretta S, Lunetta C, Riva N, Ferrarese C, Tremolizzo L. Riluzole Selective Antioxidant Effects in Cell Models Expres sing Amyotrophic Lateral Sclerosis Endophenotypes. Clin Psychopharmacol Neurosci. 2019 Aug 31;17(3):438-442. doi: 10.9758/cpn.2019.17.3.438. PMID: 31352711; PMCID: PMC6705104.
Gentile F, Scarlino S, Falzone YM, Lunetta C, Tremolizzo L, Quattrini A, Riva N. The Peripheral Nervous System in Amyotrophic Lateral Sclero sis: Opportunities for Translational Research. Front Neurosci. 2019 Jun 25;13:601. doi: 10.3389/fnins.2019.00601. PMID: 31293369; PMCID: PMC6603245.
Mora JS, Genge A, Chio A, Estol CJ, Chaverri D, Hernández M, Marín S, Mascias J, Rodriguez GE, Povedano M, Paipa A, Dominguez R, Gamez J, Salvado M, Lunetta C, Ballario C, Riva N, Mandrioli J, Moussy A, Kinet JP, Auclair C, Dubreuil P, Arnold V, Mansfield CD, Hermine O; AB10015 STUDY GROUP. Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial. Amyo troph Lateral Scler Frontotemporal Degener. 2020 Feb;21(1-2):5-14. doi: 10.1080/21678421.2019.1632346. Epub 2019 Jul 7. PMID: 31280619.
Trojsi F, Siciliano M, Femiano C, Santangelo G, Lunetta C, Calvo A, Moglia C, Marinou K, Ticozzi N, Ferro C, Scialò C, Sorarù G, Conte A, Falzone YM, Tortelli R, Russo M, Sansone VA, Chiò A, Mora G, Silani V, Volanti P, Caponnetto C, Querin G, Sabatelli M, Riva N, Logroscino G, Messina S, Fasano A, Monsurrò MR, Tedeschi G, Mandrioli J. Comparative Analysis of <i>C9orf72</i> and Sporadic Disease in a Large Multicenter ALS Population: The Effect of Male Sex on Survival of <i>C9orf72</i> Positive Patients. Front Neurosci. 2019 May 17;13:485. doi: 10.3389/fnins.2019.00485. PMID: 31156370; PMCID: PMC6534038.
Shefner JM, Cudkowicz ME, Hardiman O, Cockcroft BM, Lee JH, Malik FI, Meng L, Rudnicki SA, Wolff AA, Andrews JA; VITALITY-ALS Study Group. A phase III trial of <i>tirasemtiv</i> as a potential treatment for amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotem poral Degener. 2019;0(0):1-11. doi: 10.1080/21678421.2019.1612922. Erratum in: Amyotroph Lateral Scler Frontotemporal Degener. 2019 Jul 14;:1. PMID: 31081694.
Calvo AC, Cibreiro GA, Merino PT, Roy JF, Galiana A, Rufián AJ, Cano JM, Martín MA, Moreno L, Larrodé P, Vázquez PC, Galán L, Mora J, Muñoz Blanco JL, Muñoz MJ, Zaragoza P, Pegoraro E, Sorarù G, Mora M, Lunetta C, Penco S, Tarlarini C, Esteban J, Osta R, Redondo AG. Collagen XIX Alpha 1 Improves Prognosis in Amyotrophic Lateral Sclerosis. Aging Dis. 2019 Apr 1;10(2):278-292. doi: 10.14336/AD.2018.0917. PMID: 31011479; PMCID: PMC6457048.
Lattante S, Doronzio PN, Marangi G, Conte A, Bisogni G, Bernardo D, Russo T, Lamberti D, Patrizi S, Apollo FP, Lunetta C, Scarlino S, Pozzi L, Zollino M, Riva N, Sabatelli M. Coexistence of variants in TBK1 and in other ALS-related genes elucidates an oligogenic model of pathogenesis in sporadic ALS. Neurobiol Aging. 2019 Dec;84:239.e9-239.e14. doi: 10.1016/j.neurobiolaging.2019.03.010. Epub 2019 Mar 27. PMID: 31000212.
Spinelli EG, Agosta F, Ferraro PM, Querin G, Riva N, Bertolin C, Martinelli I, Lunetta C, Fontana A, Sorarù G, Filippi M. Brain MRI shows white matter sparing in Kennedy's disease and slow-progressing lower motor neuron disease. Hum Brain Mapp. 2019 Jul;40(10):3102-3112. doi: 10.1002/hbm.24583. Epub 2019 Mar 28. PMID: 30924230; PMCID: PMC6865482.
Visser AE, D'Ovidio F, Peters S, Vermeulen RC, Beghi E, Chiò A, Veldink JH, Logroscino G, Hardiman O, van den Berg LH; Euro-MOTOR consor tium. Multicentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk. J Neurol Neurosurg Psychiatry. 2019 Aug;90(8):854-860. doi: 10.1136/jnnp-2018-319779. Epub 2019 Mar 8. PMID: 30850472.
Conti E, Grana D, Stefanoni G, Corsini A, Botta M, Magni P, Aliprandi A, Lunetta C, Appollonio I, Ferrarese C, Tremolizzo L. Irisin and BDNF serum levels and behavioral disturbances in Alzheimer's disease. Neurol Sci. 2019 Jun;40(6):1145-1150. doi: 10.1007/s10072-019-03781-y. Epub 2019 Feb 27. PMID: 30810826.
Bandres-Ciga S, Noyce AJ, Hemani G, Nicolas A, Calvo A, Mora G; ITALSGEN Consortium; International ALS Genomics Consortium; Tienari PJ, Stone DJ, Nalls MA, Singleton AB, Chiò A, Traynor BJ. Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis. Ann Neurol. 2019 Apr;85(4):470-481. doi: 10.1002/ana.25431. Epub 2019 Mar 13. Erratum in: Ann Neurol. 2020 Jun;87(6):991-992. PMID: 30723964; PMCID: PMC6450729.
Riva N, Mora G, Sorarù G, Lunetta C, Ferraro OE, Falzone Y, Leocani L, Fazio R, Comola M, Comi G; CANALS Study Group. Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-con trolled, phase 2 trial. Lancet Neurol. 2019 Feb;18(2):155-164. doi: 10.1016/S1474-4422(18)30406-X. Epub 2018 Dec 13. PMID: 30554828.
Tarlarini C, Greco LC, Lizio A, Gerardi F, Sansone VA, Lunetta C. Taste changes in amyotrophic lateral sclerosis and effects on quality of life. Neurol Sci. 2019 Feb;40(2):399-404. doi: 10.1007/s10072-018-3672-z. Epub 2018 Dec 4. PMID: 30515604.
Sansone VA, Albamonte E, Salmin F, Casiraghi J, Pirola A, Bettinelli M, Rao F, Mancini L, Tovaglieri N, Fedeli F, Stoia P, Heinen M, Cozzi V, Car raro E, Lunetta C, Di Bari A, Mercuri E; Italian EAP working group. Intrathecal nusinersen treatment for SMA in a dedicated neuromuscular clinic: an example of multidisciplinary and integrated care. Neurol Sci. 2019 Feb;40(2):327-332. doi: 10.1007/s10072-018-3622-9. Epub 2018 Nov 15. PMID: 30430317.
Salvaggio G, Calamia M, Purpura P, Bartolotta TV, Picone D, Dispensa N, Lunetta C, Bruno A, Raso L, Salvaggio L, Lo Re G, Galia M, Simonato A, Midiri M, Lagalla R. Role of apparent diffusion coefficient values in prostate diseases characterization on diffusion-weighted magnetic reso nance imaging. Minerva Urol Nefrol. 2019 Apr;71(2):154-160. doi: 10.23736/S0393-2249.18.03065-5. Epub 2018 Nov 7. PMID: 30421590.
Lunetta C, Lizio A, Tremolizzo L, Ruscica M, Macchi C, Riva N, Weydt P, Corradi E, Magni P, Sansone V. Serum irisin is upregulated in patients affected by amyotrophic lateral sclerosis and correlates with functional and metabolic status. J Neurol. 2018 Dec;265(12):3001-3008. doi: 10.1007/s00415-018-9093-3. Epub 2018 Oct 22. PMID: 30350169.
Stoccoro A, Mosca L, Carnicelli V, Cavallari U, Lunetta C, Marocchi A, Migliore L, Coppedè F. Mitochondrial DNA copy number and D-loop region methylation in carriers of amyotrophic lateral sclerosis gene mutations. Epigenomics. 2018 Nov;10(11):1431-1443. doi: 10.2217/epi 2018-0072. Epub 2018 Aug 8. PMID: 30088417.
D'Ovidio F, Rooney JPK, Visser AE, Manera U, Beghi E, Logroscino G, Vermeulen RCH, Veldink JH, van den Berg LH, Hardiman O, Chiò A; Euro MOTOR consortium. Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study. J Neurol Neurosurg Psychiatry. 2019 Jan;90(1):11-19. doi: 10.1136/jnnp-2018-318559. Epub 2018 Aug 3. PMID: 30076269.
Mandrioli J, D'Amico R, Zucchi E, Gessani A, Fini N, Fasano A, Caponnetto C, Chiò A, Dalla Bella E, Lunetta C, Mazzini L, Marinou K, Sorarù G, de Biasi S, Lo Tartaro D, Pinti M, Cossarizza A; RAP-ALS investigators group. Rapamycin treatment for amyotrophic lateral sclerosis: Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP-ALS trial). Medicine (Baltimore). 2018 Jun;97(24):e11119. doi: 10.1097/MD.0000000000011119. PMID: 29901635; PMCID: PMC6024184.
De Mattia E, Falcier E, Lizio A, Lunetta C, Sansone VA, Barbarito N, Garabelli B, Iatomasi M, Roma E, Rao F, Carlucci A. Passive Versus Active Circuit During Invasive Mechanical Ventilation in Subjects With Amyotrophic Lateral Sclerosis. Respir Care. 2018 Sep;63(9):1132-1138. doi: 10.4187/respcare.05866. Epub 2018 May 15. PMID: 29765003.
Visser AE, Rooney JPK, D'Ovidio F, Westeneng HJ, Vermeulen RCH, Beghi E, Chiò A, Logroscino G, Hardiman O, Veldink JH, van den Berg LH; Euro-MOTOR consortium. Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):797-803. doi: 10.1136/jnnp-2017-317724. Epub 2018 Apr 23. PMID: 29685899.
Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, Van der Spek RA, Pliner HA, Shankaracharya, Smith BN, Marangi G, Topp SD, Abramzon Y, Gkazi AS, Eicher JD, Kenna A; ITALSGEN Consortium; Mora G, Calvo A, Mazzini L, Riva N, Mandrioli J, Caponnetto C, Battistini S, Volanti P, La Bella V, Conforti FL, Borghero G, Messina S, Simone IL, Trojsi F, Salvi F, Logullo FO, D'Alfonso S, Corrado L, Capasso M, Ferrucci L; Genomic Translation for ALS Care (GTAC) Consortium; Moreno CAM, Kamalakaran S, Goldstein DB; ALS Sequencing Consortium; Gitler AD, Harris T, Myers RM; NYGC ALS Consortium; Phatnani H, Musunuri RL, Evani US, Abhyankar A, Zody MC; Answer ALS Foundation; Kaye J, Finkbeiner S, Wyman SK, LeNail A, Lima L, Fraenkel E, Svendsen CN, Thompson LM, Van Eyk JE, Berry JD, Miller TM, Kolb SJ, Cudkowicz M, Baxi E; Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium; Benatar M, Taylor JP, Rampersaud E, Wu G, Wuu J; SLAGEN Consortium; Lauria G, Verde F, Fogh I, Tiloca C, Comi GP, Sorarù G, Cereda C; French ALS Consortium; Corcia P, Laaksovirta H, Myllykangas L, Jansson L, Valori M, Ealing J, Hamdalla H, Rollinson S, Pickering-Brown S, Orrell RW, Sidle KC, Malaspina A, Hardy J, Singleton AB, Johnson JO, Arepalli S, Sapp PC, McKenna-Yasek D, Polak M, Asress S, Al-Sarraj S, King A, Troakes C, Vance C, de Belleroche J, Baas F, Ten Asbroek ALMA, Muñoz-Blanco JL, Hernandez DG, Ding J, Gibbs JR, Scholz SW, Floeter MK, Campbell RH, Landi F, Bowser R, Pulst SM, Ravits JM, MacGowan DJL, Kirby J, Pioro EP, Pamphlett R, Broach J, Gerhard G, Dunckley TL, Brady CB, Kowall NW, Troncoso JC, Le Ber I, Mouzat K, Lumbroso S, Heiman-Patterson TD, Kamel F, Van Den Bosch L, Baloh RH, Strom TM, Meitinger T, Shatunov A, Van Eijk KR, de Carvalho M, Kooyman M, Middelkoop B, Moisse M, McLaughlin RL, Van Es MA, Weber M, Boylan KB, Van Blitterswijk M, Rademakers R, Morrison KE, Basak AN, Mora JS, Drory VE, Shaw PJ, Turner MR, Talbot K, Hardiman O, Williams KL, Fifita JA, Nicholson GA, Blair IP, Rouleau GA, Esteban-Pérez J, García-Redondo A, Al-Chalabi A; Project MinE ALS Sequencing Consortium; Rogaeva E, Zinman L, Ostrow LW, Maragakis NJ, Rothstein JD, Simmons Z, Cooper-Knock J, Brice A, Goutman SA, Feldman EL, Gibson SB, Taroni F, Ratti A, Gellera C, Van Damme P, Robberecht W, Fratta P, Sabatelli M, Lunetta C, Ludolph AC, Andersen PM, Weishaupt JH, Camu W, Trojanowski JQ, Van Deerlin VM, Brown RH Jr, van den
Berg LH, Veldink JH, Harms MB, Glass JD, Stone DJ, Tienari P, Silani V, Chiò A, Shaw CE, Traynor BJ, Landers JE. Genome-wide Analyses Iden tify KIF5A as a Novel ALS Gene. Neuron. 2018 Mar 21;97(6):1268-1283.e6. doi: 10.1016/j.neuron.2018.02.027. PMID: 29566793; PMCID: PMC5867896.
Mandrioli J, Ferri L, Fasano A, Zucchi E, Fini N, Moglia C, Lunetta C, Marinou K, Ticozzi N, Drago Ferrante G, Scialo C, Sorarù G, Trojsi F, Conte A, Falzone YM, Tortelli R, Russo M, Sansone VA, Mora G, Silani V, Volanti P, Caponnetto C, Querin G, Monsurrò MR, Sabatelli M, Chiò A, Riva N, Logroscino G, Messina S, Calvo A. Cardiovascular diseases may play a negative role in the prognosis of amyotrophic lateral sclerosis. Eur J Neurol. 2018 Jun;25(6):861-868. doi: 10.1111/ene.13620. Epub 2018 Apr 15. PMID: 29512869.
Lattante S, Pomponi MG, Conte A, Marangi G, Bisogni G, Patanella AK, Meleo E, Lunetta C, Riva N, Mosca L, Carrera P, Bee M, Zollino M, Saba telli M. ATXN1 intermediate-length polyglutamine expansions are associated with amyotrophic lateral sclerosis. Neurobiol Aging. 2018 Apr;64:157.e1-157.e5. doi: 10.1016/j.neurobiolaging.2017.11.011. Epub 2017 Nov 28. PMID: 29274668.
Vitacca M, Montini A, Lunetta C, Banfi P, Bertella E, De Mattia E, Lizio A, Volpato E, Lax A, Morini R, Paneroni M; ALS RESPILOM Study Group. Impact of an early respiratory care programme with non-invasive ventilation adaptation in patients with amyotrophic lateral sclerosis. Eur J Neurol. 2018 Mar;25(3):556-e33. doi: 10.1111/ene.13547. Epub 2018 Jan 29. PMID: 29266547.
Crespi C, Dodich A, Cappa SF, Canessa N, Iannaccone S, Corbo M, Lunetta C, Falini A, Cerami C. Multimodal MRI quantification of the common neurostructural bases within the FTD-ALS continuum. Neurobiol Aging. 2018 Feb;62:95-104. doi: 10.1016/j.neurobiolaging.2017.09.019. Epub 2017 Sep 28. PMID: 29131982.
Pupillo E, Poloni M, Bianchi E, Giussani G, Logroscino G, Zoccolella S, Chiò A, Calvo A, Corbo M, Lunetta C, Marin B, Mitchell D, Hardiman O, Rooney J, Stevic Z, Bandettini di Poggio M, Filosto M, Cotelli MS, Perini M, Riva N, Tremolizzo L, Vitelli E, Damiani D, Beghi E; EURALS Consor tium†. Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):118-125. doi: 10.1080/21678421.2017.1386687. Epub 2017 Oct 24. PMID: 29063790.
van Eijk RPA, Jones AR, Sproviero W, Shatunov A, Shaw PJ, Leigh PN, Young CA, Shaw CE, Mora G, Mandrioli J, Borghero G, Volanti P, Diekstra FP, van Rheenen W, Verstraete E, Eijkemans MJC, Veldink JH, Chio A, Al-Chalabi A, van den Berg LH, van Es MA; For UKMND-LiCALS and LITALS Study Group. Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials. Neurology. 2017 Oct 31;89(18):1915-1922. doi: 10.1212/WNL.0000000000004606. Epub 2017 Oct 4. Erratum in: Neurology. 2017 Nov 28;89(22):2303. PMID: 28978660; PMCID: PMC5664299.
Portaro S, Calabrò RS, Bramanti P, Silvestri G, Torrisi M, Conti-Nibali V, Caliri S, Lunetta C, Alagna B, Naro A, Bramanti A. Telemedicine for Facio- Scapulo-Humeral Muscular Dystrophy: A multidisciplinary approach to improve quality of life and reduce hospitalization rate? Disabil Health J. 2018 Apr;11(2):306-309. doi: 10.1016/j.dhjo.2017.09.003. Epub 2017 Sep 21. PMID:
28967584.
Coppedè F, Stoccoro A, Mosca L, Gallo R, Tarlarini C, Lunetta C, Marocchi A, Migliore L, Penco S. Increase in DNA methylation in patients with amyotrophic lateral sclerosis carriers of not fully penetrant SOD1 mutations. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Feb;19(1-2):93-101. doi: 10.1080/21678421.2017.1367401. Epub 2017 Sep 1. PMID: 28859526.
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